Nonenzymatic Reactions above Phospholipid Surfaces of Biological Membranes: Reactivity of Phospholipids and Their Oxidation Derivatives

Table 1

Theoretical studies about reactivity on phospholipid surfaces at DFT level of calculus.

Studied reaction	Limited step	Calculated activation energy (Kcal mol^−1)	Reference
Decomposition of hydrogen peroxide	Formation of an intermediate hydrogen trioxide	8.76	[20]
Schiff base formation between PE and acetaldehyde	Dehydration of carbinolamine intermediate	13.08	[19]
Amadori rearrangement from PE-D-erythrose Schiff base	Formation of a 1,2-enaminol intermediate	16.78	[22]
Carboxymethyl-PE formation from reaction between glyoxal and PE	Dehydration of Carbino-diol-amine intermediate	15.41	[23]
Reaction of aminoguanidine with dicarbonyl-PE product	Dehydration of an aminoguanidine adduct	—	[24]