Interaction of H₂S with Calcium Permeable Channels and Transporters

Figure 1

Hydrogen sulfide regulating L-type calcium channels by S-sulfhydration. LTCC consists of a pore-forming α subunit which contains four homologous domains (I–IV), each with six transmembrane segments (S1–S6). The S1–S4 segments are the voltage sensor, and the S5-S6 segments form the channel pore and selectivity filter. The cartoon demonstrated that H₂S modifies the –SH from sulfhydryl donor which is transformed to free cysteine sulfhydryl and forms covalent persulfide (–SSH).