Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study

Figure 1

Cumulative relative risk of death overtime after coapplication of compounds. Cumulative relative risk (RR) of death overtime with simultaneous intraperitoneal (i.p.) injection of POX, PAM and NAC, and GSH and AA. The legends on the side are depicting the treatment groups. RR was estimated by Cox [23] analysis, adjusted for POX dose (high/low) for each of the time points examined (30 min and 1, 2, 3, 4, 24, and 48 h). Best protection was conferred by simultaneous PAM treatment only and poor protection was estimated for all non-enzymatic treatment alone. Efficacy of PAM was estimated to decrement when co-administered with antioxidants.