Review Article
Protective Actions of 17β-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds
Table 1
Genes involved in antioxidative neuroprotection mediated by 17β-estradiol in the CNS.
| | Target gene (up or down) | Proposed effects | Reference(s) |
| | SOD1 (↑) | ROS elimination | [24, 28] | | SOD2 (↑) | ROS elimination | [28] | | GPx (↑) | ROS elimination | [25] | | Catalase (↑) | ROS elimination | [25] | | iNOS (↓) | Decreases in reactive radicals | [25, 69, 70] | | nNOS (↓) | Decreases in reactive radicals | [25] | | GST (↑) | Elimination of ROS-derived reactive metabolites | [30] | | NQO1 (↑) | Elimination of ROS-derived reactive metabolites | [30] | | Seladin-1 (↑) | Antiapoptosis | [33, 34] | | Neuroglobin (↑) | Antiapoptosis, anti-inflammation | [40, 41] | | IL-6 (↓) | Anti-inflammation | [41] | | IP-10 (↓) | Anti-inflammation | [41] | | MMP-9 (↓) | Anti-inflammation | [25, 69, 70] | | Cytochrome c oxidase (↑) | Increment of mitochondrial efficiency | [50] | | Bax (↓) | Antiapoptosis | [42] |
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IL-6: interleukin-6; IP-10: IFN-gamma-inducible protein 10; MMP-9: matrix metalloproteinase-9; NOS: nitric oxide synthase; NQO1, NADPH: quinone oxidoreductase 1.
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