The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease

Figure 1

Tau protein NFTs formation and autophagic dysfunction in Alzheimer’s disease. Aβ oligomers and ROS production intrigue oxidative stress and mitochondria dysfunction, in which induce tau protein hyperphosphorylation and neurofibrillary tangles formation with protein phosphatase and kinases imbalance. These events converge to autophagic dysfunction and tau protein aggregation to lead to neurodegeneration and cell death in AD.