Toll-Like Receptor 4 Promotes NO Synthesis by Upregulating GCHI Expression under Oxidative Stress Conditions in Sheep Monocytes/Macrophages

Figure 3

Overexpression of TLR4 enhances oxidative stress in monocytes/macrophages. Expression patterns of ROS, RNS, and MDA after stimulation with 1 μg/mL LPS ((a), (b), and (c), resp.). (d) TLR4 and TRX protein expression levels were detected by immunofluorescence (×200), DAPI (blue), TLR4-FITC (green), and TRX (red). Tg: transgenic sheep, WT: wild-type. Results were expressed as mean ± SE; in Tg versus WT groups.

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