Nephroprotective Effects of Polydatin against Ischemia/Reperfusion Injury: A Role for the PI3K/Akt Signal Pathway

Figure 1

Therapeutical effects of polydatin on renal I/R injury. (a) Chemical structure of polydatin; (b) blood urea nitrogen (BUN); (c) serum creatinine (Scr) in renal I/R mice that received polydatin-L (10 mg/kg), polydatin-M (20 mg/kg), polydatin-H (40 mg/kg), or vehicle (saline with 1% DMSO); (d) histological score of kidney injuries (HSK); (e) immunohistochemical staining for PCNA; and (f) TUNEL in I/R mice that received polydatin-L, polydatin-M, polydatin-H, or vehicle. versus vehicle; versus I/R 12 h respective group; versus I/R 1 d respective group; versus I/R 3 d respective group. versus I/R 5 d respective group.

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