Thiosemicarbazone <i>p</i>-Substituted Acetophenone Derivatives Promote the Loss of Mitochondrial <svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-4.1996pt" id="M1" height="15.8229pt" version="1.1" viewBox="-0.0657574 -11.6233 23.6944 15.8229" width="23.6944pt"><g transform="matrix(.017,0,0,-0.017,0,0)"><path id="g14-133" d="M631 0V33L360 665L313 654L42 33V0H631ZM467 64H130L298 484L467 64Z"/></g><g transform="matrix(.017,0,0,-0.017,11.592,0)"><path id="g14-245" d="M684 417L672 457C631 445 586 428 561 408C542 393 531 368 521 331L470 159C449 95 423 54 364 49L461 519L452 523L364 495L284 58C243 79 222 112 222 179C222 207 223 234 226 261C229 289 232 327 232 345C232 430 198 457 157 457C114 457 66 430 22 385L33 345C47 356 62 365 78 365C95 365 107 357 107 324C107 316 104 267 101 238C99 216 98 193 98 171C98 42 183 -9 274 -13L243 -187C238 -218 255 -238 267 -242L315 -195L351 -9C375 -3 406 8 428 20C473 45 512 79 547 158C575 221 605 289 619 329C632 364 646 395 684 417Z"/></g></svg>, GSH Depletion, and Death in K562 Cells

<div>Synthesis of thiosemicarbazones.</div>

Oxidative Medicine and Cellular Longevity

sch1

Scheme 1

Scheme 1: Thiosemicarbazone <i>p</i>-Substituted Acetophenone Derivatives Promote the Loss of Mitochondrial <svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-4.1996pt" id="M1" height="15.8229pt" version="1.1" viewBox="-0.0657574 -11.6233 23.6944 15.8229" width="23.6944pt"><g transform="matrix(.017,0,0,-0.017,0,0)"><path id="g14-133" d="M631 0V33L360 665L313 654L42 33V0H631ZM467 64H130L298 484L467 64Z"/></g><g transform="matrix(.017,0,0,-0.017,11.592,0)"><path id="g14-245" d="M684 417L672 457C631 445 586 428 561 408C542 393 531 368 521 331L470 159C449 95 423 54 364 49L461 519L452 523L364 495L284 58C243 79 222 112 222 179C222 207 223 234 226 261C229 289 232 327 232 345C232 430 198 457 157 457C114 457 66 430 22 385L33 345C47 356 62 365 78 365C95 365 107 357 107 324C107 316 104 267 101 238C99 216 98 193 98 171C98 42 183 -9 274 -13L243 -187C238 -218 255 -238 267 -242L315 -195L351 -9C375 -3 406 8 428 20C473 45 512 79 547 158C575 221 605 289 619 329C632 364 646 395 684 417Z"/></g></svg>, GSH Depletion, and Death in K562 Cells 

Oxidative Medicine and Cellular Longevity

Thiosemicarbazone p-Substituted Acetophenone Derivatives Promote the Loss of Mitochondrial , GSH Depletion, and Death in K562 Cells

Scheme 1