Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation

Figure 5

Mitochondrial oxidative stress is augmented in the hearts of DCM animals. (a) Representative EPR spectra of heart tissue homogenates measured at 77 K. Semiquinone free radicals and Fe(III) from Fe-S centers signals are seen at and , respectively. EPR signal amplitude was normalized against the weight of the heart and expressed as arbitrary units per gram. (b) Normalized EPR signal amplitude of the Fe-S centers ( hearts). (c) Normalized EPR signal amplitude of the semiquinone radical ( hearts, ). Data are represented as mean ± SEM. Significant differences between mean values were determined using Student’s -test.

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