Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation
Mitochondrial oxidative stress is augmented in the hearts of DCM animals. (a) Representative EPR spectra of heart tissue homogenates measured at 77 K. Semiquinone free radicals and Fe(III) from Fe-S centers signals are seen at and , respectively. EPR signal amplitude was normalized against the weight of the heart and expressed as arbitrary units per gram. (b) Normalized EPR signal amplitude of the Fe-S centers ( hearts). (c) Normalized EPR signal amplitude of the semiquinone radical ( hearts, ). Data are represented as mean ± SEM. Significant differences between mean values were determined using Student’s -test.