TrkB-Mediated Neuroprotective and Antihypoxic Properties of Brain-Derived Neurotrophic Factor
Spontaneous bioelectrical activity in dissociated hippocampal cultures. ((a1)-(a2)) Neural network activity during the first 10 min of hypoxia. (a1) number of network bursts per min; (a2) number of spikes per sec; ((b1)–(b3)) Raster plots of electrical spiking activity from 64 electrodes (lower rows) and a diagram of the total spike rate (upper row) in primary hippocampal cultures. (b1) hypoxia; (b2) hypoxia + BDNF; (b3) hypoxia + BDNF + k252a. ((c1)-(c2)) Neural network activity on day 7 after hypoxia; (c1) number of network bursts per 10 min; (c2) number of spikes per burst; ((d1)-(d2)) spike recording from 4 electrodes of the MED64 probe. (d1) before hypoxia; (d2) on 7 day after hypoxia. (: versus “Sham”; : versus “hypoxia + BDNF”; #: versus “hypoxia”, ANOVA , ).
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