Oxidative Stress Responses and NRF2 in Human Leukaemia

Figure 1

Glutathione synthesis as seen through NRF2. GSH is a two-step synthesis reaction catalysed by glutamate-cysteine ligase (GCL) and GSH synthetase. GSH is consumed in many ways, such as by oxidation or conjugation. In addition, cells may lose GSH due to export of its reduced, oxidized, or conjugated forms and intracellular GSH is regenerated via reduction at the expense of one NADPH molecule. Highlighted in red are the genes regulated by NRF2 activity.