Review Article
Hydrogen Sulfide: A Therapeutic Candidate for Fibrotic Disease?
Figure 1
The effects of H2S on various cells associated with fibrosis. H2S inhibits neutrophil infiltration and macrophage activation during the inflammation response. H2S inhibits fibroblast proliferation and differentiation to myofibroblasts. In epithelial cells, H2S inhibits the epithelial-mesenchymal transition (EMT) process induced by various insults and cytokines. ECM: extracellular matrix.