Development of Antiatherosclerotic Drugs on the basis of Natural Products Using Cell Model Approach

Figure 4

Antiatherosclerotic effect of wheat seedlings in ex vivo model. The study involved 8 volunteers (5 males, 3 females, mean age years) whose blood serum induced 1.7–2.3-fold increase in cholesterol content of cells cultured from unaffected human aortic intima (the average level of serum atherogenicity was %). Intracellular cholesterol in control cultures was  mg/mg cell protein. Baseline serum atherogenicity was taken as 100%. The average values of changes of serum atherogenicity with indication of standard errors are presented. Significant decrease of serum atherogenicity, .