Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 478039, 9 pages
http://dx.doi.org/10.1155/2015/478039
Research Article

Xanthine Oxidase Inhibitor, Allopurinol, Prevented Oxidative Stress, Fibrosis, and Myocardial Damage in Isoproterenol Induced Aged Rats

Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh

Received 13 February 2015; Revised 9 May 2015; Accepted 12 May 2015

Academic Editor: Kota V. Ramana

Copyright © 2015 Md. Abu Taher Sagor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Andrés, A. Cordero, P. Magán et al., “Long-term mortality and hospital readmission after acute myocardial infarction: an eight-year follow-up study,” Revista Espanola de Cardiologia, vol. 65, no. 5, pp. 414–420, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. V. L. Roger, A. S. Go, D. M. Lloyd-Jones et al., “Heart disease and stroke statistics—2011 update: a report from the American Heart Association,” Circulation, vol. 123, no. 4, pp. e18–e209, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. P. R. Hansen, “Role of neutrophils in myocardial ischemia and reperfusion,” Circulation, vol. 91, no. 6, pp. 1872–1885, 1995. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Rathore, S. John, M. Kale, and D. Bhatnagar, “Lipid peroxidation and antioxidant enzymes in isoproterenol induced oxidative stress in rat tissues,” Pharmacological Research, vol. 38, no. 4, pp. 297–303, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Zaragoza, C. Gomez-Guerrero, J. L. Martin-Ventura et al., “Animal models of cardiovascular diseases,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 497841, 13 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Ou, W. Li, Y. Liu et al., “Animal models of cardiac disease and stem cell therapy,” Open Cardiovascular Medicine Journal, vol. 4, no. 2, pp. 231–239, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. A. J. Serra, M. H. H. Santos, D. S. Bocalini et al., “Exercise training inhibits inflammatory cytokines and more than prevents myocardial dysfunction in rats with sustained β-adrenergic hyperactivity,” Journal of Physiology, vol. 588, no. 13, pp. 2431–2442, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Zhang, A. Knapton, S. E. Lipshultz, J. L. Weaver, and E. H. Herman, “Isoproterenol-induced cardiotoxicity in sprague-dawley rats: correlation of reversible and irreversible myocardial injury with release of cardiac troponin T and roles of iNOS in myocardial injury,” Toxicologic Pathology, vol. 36, no. 2, pp. 277–278, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. A. P. Davel, P. C. Brum, and L. V. Rossoni, “Isoproterenol induces vascular oxidative stress and endothelial dysfunction via a Giα-coupled β2-adrenoceptor signaling pathway,” PLoS ONE, vol. 9, no. 3, Article ID e91877, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Díaz-Muñoz, M. A. Álvarez-Pérez, L. Yáñnez et al., “Correlation between oxidative stress and alteration of intracellular calcium handling in isoproterenol-induced myocardial infarction,” Molecular and Cellular Biochemistry, vol. 289, no. 1-2, pp. 125–136, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Rodrigo, M. Libuy, F. Feliú, and D. Hasson, “Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage,” Disease Markers, vol. 35, no. 6, pp. 773–790, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. J. L. Zweier and M. A. H. Talukder, “The role of oxidants and free radicals in reperfusion injury,” Cardiovascular Research, vol. 70, no. 2, pp. 181–190, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Takimoto and D. A. Kass, “Role of oxidative stress in cardiac hypertrophy and remodeling,” Hypertension, vol. 49, no. 2, pp. 241–248, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. T. P. Cappola, D. A. Kass, G. S. Nelson et al., “Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy,” Circulation, vol. 104, no. 20, pp. 2407–2411, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Engberding, S. Spiekermann, A. Schaefer et al., “Allopurinol attenuates left ventricular remodeling and dysfunction after experimental myocardial infarction: a new action for an old drug?” Circulation, vol. 110, no. 15, pp. 2175–2179, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. K. M. Minhas, R. M. Saraiva, K. H. Schuleri et al., “Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathy,” Circulation Research, vol. 98, no. 2, pp. 271–279, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. W. G. Niehaus Jr. and B. Samuelsson, “Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation,” European Journal of Biochemistry, vol. 6, no. 1, pp. 126–130, 1968. View at Publisher · View at Google Scholar · View at Scopus
  18. W. R. Tracey, J. Tse, and G. Carter, “Lipopolysaccharide-induced changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors,” Journal of Pharmacology and Experimental Therapeutics, vol. 272, no. 3, pp. 1011–1015, 1995. View at Google Scholar · View at Scopus
  19. V. Witko-Sarsat, M. Friedlander, C. Capeillère-Blandin et al., “Advanced oxidation protein products as a novel marker of oxidative stress in uremia,” Kidney International, vol. 49, no. 5, pp. 1304–1313, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. B. K. Tiwari, D. Kumar, A. B. Abidi, and S. I. Rizvi, “Efficacy of composite extract from leaves and fruits of medicinal plants used in traditional diabetic therapy against oxidative stress in alloxan-induced diabetic rats,” ISRN Pharmacology, vol. 2014, Article ID 608590, 7 pages, 2014. View at Publisher · View at Google Scholar
  21. R. A. Khan, “Protective effects of Sonchus asper (L.) Hill, (Asteraceae) against CCl4-induced oxidative stress in the thyroid tissue of rats,” BMC Complementary and Alternative Medicine, vol. 12, no. 1, article 181, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Chance and A. C. Maehly, “Assay of catalase and peroxidases,” Methods in Enzymology, vol. 11, pp. 764–775, 1955. View at Publisher · View at Google Scholar · View at Scopus
  23. D. J. Jollow, J. R. Mitchell, N. Zampaglione, and J. R. Gillette, “Bromobenzene induced liver necrosis. Protective role of glutathione and evidence for 3,4 bromobenzene oxide as the hepatotoxic metabolite,” Pharmacology, vol. 11, no. 3, pp. 151–169, 1974. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Vennila and K. V. Pugalendi, “Protective effect of sesamol against myocardial infarction caused by isoproterenol in Wistar rats,” Redox Report, vol. 15, no. 1, pp. 36–42, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. V. Patel, A. Upaganlawar, R. Zalawadia, and R. Balaraman, “Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: a biochemical, electrocardiographic and histoarchitectural evaluation,” European Journal of Pharmacology, vol. 644, no. 1–3, pp. 160–168, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. P. K. Singal, R. E. Beamish, and N. S. Dhalla, “Potential oxidative pathways of catecholamines in the formation of lipid peroxides and genesis of heart disease,” Advances in Experimental Medicine and Biology, vol. 161, pp. 391–401, 1983. View at Google Scholar · View at Scopus
  27. L. Liaudet, B. Calderari, and P. Pacher, “Pathophysiological mechanisms of catecholamine and cocaine-mediated cardiotoxicity,” Heart Failure Reviews, vol. 19, no. 6, pp. 815–824, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Mladěnka, R. Hrdina, Z. Bobrovová et al., “Cardiac biomarkers in a model of acute catecholamine cardiotoxicity,” Human and Experimental Toxicology, vol. 28, no. 10, pp. 631–640, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. C. E. Berry and J. M. Hare, “Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications,” Journal of Physiology, vol. 555, no. 3, pp. 589–606, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Jia, P. Dong, Y. Ye, C. Qian, and Q. Dai, “Allopurinol attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction,” Cardiovascular Therapeutics, vol. 30, no. 2, pp. 117–123, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. X. Gao, Y. Xu, B. Xu et al., “Allopurinol attenuates left ventricular dysfunction in rats with early stages of streptozotocin-induced diabetes,” Diabetes/Metabolism Research and Reviews, vol. 28, no. 5, pp. 409–417, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Li, W. Yao, M. G. Irwin et al., “Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1,” Free Radical Biology and Medicine, vol. 84, pp. 311–321, 2015. View at Publisher · View at Google Scholar
  33. K. H. Sabeena Farvin, R. Anandan, S. H. S. Kumar, K. S. Shiny, T. V. Sankar, and T. K. Thankappan, “Effect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in rats,” Pharmacological Research, vol. 50, no. 3, pp. 231–236, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. S. B. Rosalki, R. Roberts, H. A. Katus, E. Giannitsis, J. H. Ladenson, and F. S. Apple, “Cardiac biomarkers for detection of myocardial infarction: perspectives from past to present,” Clinical Chemistry, vol. 50, no. 11, pp. 2205–2213, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. S.-B. Wang, S. Tian, F. Yang, H.-G. Yang, X.-Y. Yang, and G.-H. Du, “Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats,” European Journal of Pharmacology, vol. 615, no. 1–3, pp. 125–132, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. K. K. Mueen Ahmed, A. C. Rana, and V. K. Dixit, “Effect of Calotropis procera latex on isoproterenol induced myocardial infarction in albino rats,” Phytomedicine, vol. 11, no. 4, pp. 327–330, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. V. D. Pinto, G. J. S. Cutini, C. L. Sartório, A. S. Paigel, D. V. Vassallo, and I. Stefanon, “Enhanced β-adrenergic response in rat papillary muscle by inhibition of inducible nitric oxide synthase after myocardial infarction,” Acta Physiologica, vol. 190, no. 2, pp. 111–117, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. D. Li, Y. Qu, L. Tao et al., “Inhibition of iNOS protects the aging heart against β-adrenergic receptor stimulation-induced cardiac dysfunction and myocardial ischemic injury,” Journal of Surgical Research, vol. 131, no. 1, pp. 64–72, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. J. Wu, J. G. Hecker, and N. Chiamvimonvat, “Antioxidant enzyme gene transfer for ischemic diseases,” Advanced Drug Delivery Reviews, vol. 61, no. 4, pp. 351–363, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. S. K. Wattanapitayakul and J. A. Bauer, “Oxidative pathways in cardiovascular disease: roles, mechanisms, and therapeutic implications,” Pharmacology and Therapeutics, vol. 89, no. 2, pp. 187–206, 2001. View at Publisher · View at Google Scholar · View at Scopus
  41. K. Karthikeyan, B. R. S. Bai, and S. N. Devaraj, “Cardioprotective effect of grape seed proanthocyanidins on isoproterenol-induced myocardial injury in rats,” International Journal of Cardiology, vol. 115, no. 3, pp. 326–333, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Rajadurai and P. S. M. Prince, “Preventive effect of naringin on lipid peroxides and antioxidants in isoproterenol-induced cardiotoxicity in Wistar rats: biochemical and histopathological evidences,” Toxicology, vol. 228, no. 2-3, pp. 259–268, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. D. Closa and E. Folch-Puy, “Oxygen free radicals and the systemic inflammatory response,” IUBMB Life, vol. 56, no. 4, pp. 185–191, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. T. M. Behr, X. Wang, N. Aiyar et al., “Monocyte chemoattractant protein-1 is upregulated in rats with volume-overload congestive heart failure,” Circulation, vol. 102, no. 11, pp. 1315–1322, 2000. View at Publisher · View at Google Scholar · View at Scopus
  45. A. Nicoletti, D. Heudes, C. Mandet, N. Hinglais, J. Bariety, and J.-B. Michel, “Inflammatory cells and myocardial fibrosis: spatial and temporal distribution in renovascular hypertensive rats,” Cardiovascular Research, vol. 32, no. 6, pp. 1096–1107, 1996. View at Publisher · View at Google Scholar · View at Scopus
  46. N. Hinglais, D. Heudes, A. Nicoletti et al., “Colocalization of myocardial fibrosis and inflammatory cells in rats,” Laboratory Investigation, vol. 70, no. 2, pp. 286–294, 1994. View at Google Scholar · View at Scopus
  47. A. Panizo, F. J. P. Mindall, M. F. Galindo, E. Cenarruzabeitia, M. Hernandez, and J. Diez, “Are mast cells involved in hypertensive heart disease?” Journal of Hypertension, vol. 13, no. 10, pp. 1201–1208, 1995. View at Publisher · View at Google Scholar · View at Scopus
  48. N. Shiota, J. Rysä, P. T. Kovanen, H. Ruskoaho, J. O. Kokkonen, and K. A. Lindstedt, “A role for cardiac mast cells in the pathogenesis of hypertensive heart disease,” Journal of Hypertension, vol. 21, no. 10, pp. 1935–1944, 2003. View at Publisher · View at Google Scholar · View at Scopus
  49. D. A. B. Kasal, M. F. Neves, W. Oigman, and C. A. Mandarim-de-Lacerda, “Allopurinol attenuates L-NAME induced cardiomyopathy comparable to blockade of angiotensin receptor,” Histology and Histopathology, vol. 23, no. 10, pp. 1241–1248, 2008. View at Google Scholar · View at Scopus