DNA Damage and Inhibition of Akt Pathway in MCF-7 Cells and Ehrlich Tumor in Mice Treated with 1,4-Naphthoquinones in Combination with Ascorbate

Figure 3

Ehrlich ascites carcinoma inhibition (a) and survival time (b) in animals treated with juglone, Q7, or Q9 at 1 mg/kg alone or in combination with ascorbate (Asc) at 100 mg/kg. Doxorubicin was administered at 1.2 mg/kg for the positive control. Lipid peroxidation (c), DNA damage (d), and phosphorylated proteins Akt (pAkt) and H2AX (γH2AX) in ascitic cells from mice (e). () and () denote difference at and compared to the negative control or between indicated treatments.

(a)

(b)

(c)

(d)

(e)