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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 502107, 8 pages
Research Article

Oxidative Stress State Is Associated with Left Ventricular Mechanics Changes, Measured by Speckle Tracking in Essential Hypertensive Patients

1UMAE Hospital de Cardiología, Centro Médico Nacional Siglo XXI, IMSS, 06720 Mexico City, DF, Mexico
2Departamento de Fisiología, Facultad de Medicina, UNAM, 04510 Mexico City, DF, Mexico
3Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, 14269 Mexico City, DF, Mexico

Received 22 January 2015; Revised 24 May 2015; Accepted 29 June 2015

Academic Editor: Raj Soorappan

Copyright © 2015 Luis Antonio Moreno-Ruíz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The oxidative stress state is characterized by an increase in oxygen reactive species that overwhelms the antioxidant defense; we do not know if these pathological changes are correlated with alterations in left ventricular mechanics. The aim was correlating the oxidative stress state with the left ventricular global longitudinal strain (GLS) and the left ventricular end diastolic pressure (LVEDP). Twenty-five patients with essential hypertension and 25 controls paired by age and gender were studied. All of the participants were subjected to echocardiography and biochemical determination of oxidative stress markers. The hypertensive patients, compared with control subjects, had significantly () higher levels of oxidized proteins ( versus  nmol/mg), lower levels of extracellular superoxide dismutase (EC-SOD) activity ( versus  U/mg), higher LVEDP ( versus  mm Hg), and lower GLS (−12% versus −16%). Both groups had preserved ejection fraction and the results showed a positive correlation of oxidized proteins with GLS (, ) and LVEDP (, ); we also found a negative correlation of EC-SOD activity with GLS (, ) and LVEDP (, ).