Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer’s Disease

Figure 1

Mitochondrial dysfunction in AD. Factors that contributed to AD such as injury, aging, and inflammation can affect three critical aspects of mitochondrial function: (1) mitochondrial dynamics (inducing fragmentation), (2) bioenergetics (ATP and ROS production), and (3) mitochondrial movement (synaptic function). ATP: adenosine triphosphate; ΔΨ: mitochondrial membrane potential; ROS: reactive oxygen species.