Treatment of β-Thalassemia/Hemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State

Table 3

Procoagulation parameters, markers of platelet activation, and blood coagulation tests in responders.

Parameters	Curcuminoids cocktail ()				Vitamin E cocktail ()
	Baseline	Month 6	Month 12	Month 15	Baseline	Month 6	Month 12	Month 15
Procoagulation parameters
PF3-like activity (A405)	1.15 ± 0.12	0.86 ± 0.09	0.78 ± 0.10^a	1.16 ± 0.16	1.24 ± 0.10	0.84 ± 0.08^b	0.67 ± 0.06^b	1.17 ± 0.12
PS^+RBC (%)	4.49 ± 0.71	1.90 ± 0.36^b	1.64 ± 0.44^b	4.18 ± 0.79	5.41 ± 1.03	2.10 ± 0.65^a	1.73 ± 0.71^b	3.55 ± 1.28
PS^+Plt (%)	1.02 ± 0.32	0.56 ± 0.16	0.40 ± 0.14	1.16 ± 0.32	0.61 ± 0.15	0.31 ± 0.06	0.24 ± 0.04^a	0.61 ± 0.16
Platelet activation
CD62 expression (%)	21.9 ± 4.0	9.0 ± 1.9^b	13.8 ± 3.2	18.1 ± 3.9	16.9 ± 3.1	7.8 ± 2.1	12.3 ± 3.3	20.0 ± 4.6
PAC1 expression (%)	3.8 ± 1.0	0.9 ± 0.3^b	2.0 ± 0.6^a	2.4 ± 0.7	4.6 ± 1.1	1.1 ± 0.5^a	2.7 ± 1.0	4.1 ± 1.5
Blood coagulation
PT (s)	15.1 ± 0.2	14.0 ± 0.2^b	14.4 ± 0.2	14.5 ± 0.4	14.9 ± 0.2	13.9 ± 0.2^b	14.2 ± 0.2^b	14.6 ± 0.2
aPTT (s)	31.3 ± 0.6	28.9 ± 0.6^a	29.3 ± 0.8^a	29.6 ± 0.8	30.8 ± 0.3	29.1 ± 0.4^b	29.0 ± 0.5^b	29.4 ± 0.5^a
PT/aPTT	0.50 ± 0.01	0.47 ± 0.01^a	0.49 ± 0.01	0.50 ± 0.01	0.50 ± 0.01	0.47 ± 0.01^a	0.49 ± 0.01	0.49 ± 0.01

The values represent mean ± standard error of the mean.
aPTT: activated partial thromboplastin time; CD62: platelet surface P-selectin; PAC1: activated glycoprotein IIb/IIIa; PF3: platelet factor 3; Plt: platelet; PS⁺: phosphatidylserine-positive; PT: prothrombin time; RBC: red blood cells.
compared with baseline, compared with baseline.