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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 543134, 8 pages
http://dx.doi.org/10.1155/2015/543134
Research Article

Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns

1Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Neonatal Intensive Care, University of Messina, Messina, Italy
2Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Child Neurology and Psychiatry, University of Messina, Messina, Italy
3Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Pediatric Genetics and Immunology, University of Messina, Messina, Italy
4Department of Economical, Business and Environmental Sciences and Quantitative Methods, University of Messina, Messina, Italy
5Department of Biomedical Sciences and Morpho-Functional Imaging, University of Messina, Messina, Italy
6Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Neonatology, University of Messina, Messina, Italy

Received 2 October 2014; Revised 29 January 2015; Accepted 29 January 2015

Academic Editor: Felipe Dal-Pizzol

Copyright © 2015 Lucia M. Marseglia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Higher total homocysteine (tHcy) levels, and C677T and A1298C methylenetetrahydrofolate (MTHFR) polymorphisms, have been reported in preterm or full term newborns with neonatal encephalopathy following perinatal hypoxic-ischemic insult. This study investigated the causal role of tHcy and MTHFR polymorphisms together with other acquired risk factors on the occurrence of brain white matter abnormalities (WMA) detected by cranial ultrasound scans (cUS) in a population of late preterm and full term infants. A total of 171 newborns (81 M, 47.4%), 45 (26.3%) born <37 wks, and 126 (73.7%) born ≥37 wks were recruited in the study. cUS detected predominant WMA pattern in 36/171 newborns (21.1%) mainly characterized by abnormal periventricular white matter signal and mild-to-moderate periventricular white matter volume loss with ventricular dilatation (6/36, 16.6%). WMA resulted in being depending on tHcy levels , lower GA , lower Apgar score at 1 minutes and 5 minutes , and 1298AC and 677CT/1298AC genotypes ( and ). In conclusion, both acquired and genetic predisposing antenatal factors were significantly associated with adverse neonatal outcome and WMA. The role of A1298C polymorphism may be taken into account for prenatal assessment and treatment counseling.