Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns
Table 2
values of Spearman correlation test between plasma tHcy levels and WMA with nonparametric variables.
Significance of covariation of the examined variables and tHcy levels
values
Sex (M versus F)
0.223
Type of pregnancy
0.225
Steroids
0.718
Tocolytics
0.332
Progestins
0.240
Cardioaspirin
0.084
Emergency cesarean section
0.352
Preeclampsia
0.413
PROM
0.013*
Bradycardia
0.636
Altered flussimetry
0.664
Fetal distress
0.444
BW
0.531
GA
0.670
Apgar 1 min
0.446
Apgar 5 min
0.298
WMA
0.081
IVH
0.864
Ventricular-peritoneal catheter
0.454
PFO
0.042*
Neonatal infections
0.201
Neonatal seizures
0.281
MTHFR genotypes
677CT
0.276
677TT
0.053
1298AC
0.000*
1298CC
0.232
677CT/1298AC
0.000*
Nonparametric variables correlated to WMA
values
677CT
0.041*
677TT
0.848
1298AC
0.000*
677CT/1298AC
0.000*
Statistical significance. tHcy: total homocysteine; MTHFR: methylenetetrahydrofolate reductase; WMA: white matter abnormalities; IVH: intraventricular hemorrhage; PROM: premature rupture of membranes; BW: birth weight; PFO: patent foramen ovale; CT and TT: heterozygous and homozygous MTHFR 677 genotypes; AC and CC: heterozygous and homozygous MTHFR 1298 genotypes.
