Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns

Table 3

Linear regression model showed dependence of Apgar score at 5 minutes, PFO, and PROM from tHcy levels.

tHcy	values
Type of pregnancy	0.958
BW	0.624
GA	0.374
Apgar 1	0.065
Apgar 5	0.002^*
Steroids	0.066
Tocolytics	0.545
Progestins	0.535
Cardioaspirin	0.167
Preeclampsia	0.447
Emergency cesarean section	0.704
PROM	0.007^*
Bradycardia	0.945
PFO	0.024^*
Altered flussimetry	0.469

Statistical significance, . GA: gestational age; tHcy: total homocysteine; MTHFR: methylenetetrahydrofolate reductase; PROM: premature rupture of membranes; BW: birth weight; PFO: patent foramen ovale.