Association of the Apolipoprotein E 2 Allele with Concurrent Occurrence of Endometrial Hyperplasia and Endometrial Carcinoma
Table 5
The distribution of genotypes in patients with EH + ECa with different tumor grades.
Genes and genotypes
Grade I (G1) Number (%)
Grade II-III (G2-3) Number (%)
P crude OR (95% CI)
P mult OR (95% CI)
COMT rs4680 G1947A Val158Met
G/G
9 (26.47)
8 (27.6)
0.34 (rec)
0.34 (rec)
G/A
19 (55.88)
14 (48.3)
1.78
1.81
A/A
6 (17.65)
7 (24.1)
(0.54–5.90)
(0.54–6.10)
HFE rs1800562 G845A Cys282Tyr
G/G
32 (94.1)
28 (90.3)
0.57 (dom)
0.52 (dom)
G/A
2 (5.9)
3 (9.7)
1.71
1.85
A/A
0 (0.0)
0 (0.0)
(0.27–11.01)
(0.28–12.42)
HFE rs1799945 C187G His63Asp
C/C
28 (82.3)
21 (67.7)
0.17 (dom)
0.14 (dom)
C/G
6 (17.6)
10 (32.3)
2.22
2.48
G/G
0 (0.0)
0 (0.0)
(0.70–7.09)
(0.73–8.44)
APOE rs7412 C526T Arg158Cys (E2 allele)
C/C
19 (55.9)
23 (74.2)
0.12 (dom)
0.10 (dom)
C/T
14 (41.2)
8 (25.8)
0.44
0.40
T/T
1 (2.9)
0 (0.0)
(0.15–1.26)
(0.13–1.22)
APOE rs429358 T388C Cys112Arg (E4 allele)
T/T
28 (82.3)
20 (64.5)
0.10 (dom)
0.097 (dom)
T/C
5 (14.7)
11 (35.5)
2.57
2.61
C/C
1 (2.9)
0 (0.0)
(0.81–8.09)
(0.82–8.29)
The choice of each genetic model was based on AIC value. The genetic model: rec, recessive; dom, dominant. OR, odds ratio; CI, confidence interval; mult, multivariate. In multivariate analysis we adjusted for age, BMI, hypertension, diabetes, smoking habits, and using of HRT.
