Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

Figure 2

Schematic presentation of the CNS cell mediated demyelination and neurodegeneration. CNS injury, for example, during infection or due to neuronal damage, leads to the activation of astrocytes and microglia. This induces the secretion of ROS, RNS, and proinflammatory cytokines and chemokines. These factors then can promote demyelination and axonal damage, finally leading to neurodegeneration.