Protective Role of Nuclear Factor E2-Related Factor 2 against Acute Oxidative Stress-Induced Pancreatic β-Cell Damage
Deficiency of Nrf2 results in reduced expression of antioxidant genes and sensitization to H2O2-induced damage in isolated mouse islets. (a) Nrf2−/− islets exhibit reduced expression of antioxidant genes. Total RNA was extracted from isolated islets that were cultured for 48 hrs. . versus Nrf2+/+ islets. (b) Representative images of cultured islets that have been exposed to 50 μM H2O2 for indicated time. The islets were examined by an Olympus SZX7 Zoom Stereomicroscope (4x). (c) Count of intact islets left following H2O2 exposure as shown in (b).
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