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Oxidative Medicine and Cellular Longevity
Volume 2015 (2015), Article ID 659687, 11 pages
Review Article

Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging

1Department of Life, Health and Environmental Sciences, University of L’Aquila, Via Vetoio, 67100 L’Aquila, Italy
2Infertility Service, San Salvatore Hospital, Via Vetoio, 67100 L’Aquila, Italy
3Institute of Translational Pharmacology (IFT), National Council of Research (CNR), 67100 L’Aquila, Italy

Received 14 June 2014; Revised 13 October 2014; Accepted 4 November 2014

Academic Editor: Mahesh Thirunavukkarasu

Copyright © 2015 Carla Tatone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In search for strategies aimed at preventing oxidative threat to female fertility, a possible role of sirtuins has emerged. Sirtuins (silent information regulator 2 (Sir2) proteins), NAD+ dependent enzymes with deacetylase and/or mono-ADP-ribosyltransferase activity, are emerging as key antiaging molecules and regulators in many diseases. Recently, a crucial role for SIRT1 and SIRT3, the main components of sirtuin family, as sensors and guardians of the redox state in oocytes, granulosa cells, and early embryos has emerged. In this context, the aim of the present review is to summarize current knowledge from research papers on the role of sirtuins in female fertility with particular emphasis on the impairment of SIRT1 signalling with oocyte aging. On this basis, the authors wish to build up a framework to promote research on the possible role of sirtuins as targets for future strategies for female fertility preservation.