Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging

Table 1

Sirtuins and related functions in the ovary.

Sirtuin	Intracellular localization	Ovarian cell type	Species	Function	Mediator	References
		Ovary	Rat	Folliculogenesis	mTOR; FOXO3a; NRF-1; SIRT6	Luo et al. [92]; Zhang et al. [93]; Wang et al. [94]
			Human	Proliferation; activation of steroidogenesis	Visfatin	Reverchon et al. [102]
		Granulosa cells	Porcine	Proliferation; secretory activity	p53; NF-κB; MAPK; ERK1-2	Pavlová et al. [97]; Sirotkin et al. [99]
			Rat	Mediation of FSH action; activation of steroidogenesis	StAR	Morita et al. [98]
SIRT1	Cytoplasmic; Nuclear	KGN		Cell homeostasis; response to metformin; activation of steroidogenesis; proliferation	FOXL2; visfatin	Benayoun et al. [96]; Cantó et al. [100]; Caton et al. [101]; Reverchon et al. [102]
		COV434		Cell homeostasis	FOXL2	Benayoun et al. [96]
		Oocyte	Mouse	Chromatin configuration; maturation; oxidative stress response; aging process	FOXO3a; miR-132; SOD2	Kawamura et al. [89]; Manosalva and González [90]; Di Emidio et al. [91]
			Porcine	Maturation		Wang et al. [94]
		Embryo	Porcine	Embryo development; regulation of apoptosis		Kwak et al. [112]
SIRT2	Cytoplasmic; Nuclear	Oocyte	Mouse	Metaphase II spindle assembly and chromosome alignment; aging process	Histone H4K16 and -tubulin	Kawamura et al. [89]; Zhang et al. [110]
		Embryo	Porcine	Embryo development; regulation of apoptosis		Kwak et al. [112]
		Granulosa cells	Human	Follicle metabolism; aging process; folliculogenesis; luteinization; progesterone secretion; oxidative stress response	GDH; SOD1; CAT; 17HSD1; StAR; P450arom	Pacella-Ince et al. [104]; Fu et al. [105]
		COV434		Folliculogenesis; luteinization; progesterone secretion	SOD1; CAT; 17HSD1; StAR; P450arom	Fu et al. [105]
SIRT3	Mitochondrial	Cumulus cells	Human	Follicle metabolism; aging process	GDH	Pacella-Ince et al. [104]
		Oocyte	Mouse	Oxidative stress response; maintenance of mitochondrial functionality		Kawamura et al. [89]
		Embryos	Mouse	Embryo development; oxidative stress response; maintenance of mitochondrial functionality	p53	Kawamura et al. [89]
			Porcine	Embryo development; regulation of apoptosis; marker of embryo potential		Kwak et al. [112]
SIRT4	Mitochondrial	Oocyte	Mouse	Function not investigated		Kawamura et al. [89]
SIRT5	Mitochondrial	Oocyte	Mouse	Function not investigated		Kawamura et al. [89]
SIRT6	Nuclear	Ovary	Rat	Folliculogenesis	mTOR; FOXO3a; NRF-1; SIRT6	Luo et al. [92]; Zhang et al. [93]; Wang et al. [94]
		Oocyte	Mouse	Follicle development		Kawamura et al. [89]; Wang et al. [94]
SIRT7	Nuclear	Oocyte	Mouse	Function not investigated		Kawamura et al. [89]