Regulation of MUTYH, a DNA Repair Enzyme, in Renal Proximal Tubular Epithelial Cells

Figure 5

MUTYH immunoreactivity in kidneys from patients with diabetic nephropathy. Representative images from two groups of patients: mild fibrosis (a) and severe fibrosis (b). MUTYH staining was observed in renal tubules (c) but was minimal in glomeruli and interstitium (d). Intense MUTYH staining was visible in tubules in kidneys with severe fibrosis (e) and the IOD (integral optical density) for MUTYH was statistically higher in the severe fibrosis group than in the mild group ((f), ).

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