OGG1 Involvement in High Glucose-Mediated Enhancement of Bupivacaine-Induced Oxidative DNA Damage in SH-SY5Y Cells

Figure 2

Proliferation effects of bupivacaine on SH-SY5Y cells and the effect of bupivacaine on the OGG1 protein expression. (a) After serum starved DMEM/F12 medium for 24 h, the cell was exposed to 0.5, 1.0, 1.5, 2.0, 2.5, or 3.0 mM bupivacaine for 24 h. Bupivacaine-induced cell injury was detected by CCK8 assay. (b) The OGG1 protein expression in SH-SY5Y cells serum starved for 24 h, followed by incubation with increasing bupivacaine concentrations (0.5, 1.0, and 2.0 mM) for 24 h. Data are presented as mean ± SD (). Compared with the group Con, .

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