Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Systems Contributing to Muscle Wasting in Chronic Kidney Disease

Table 1

Biochemical data evaluating kidney function.

	Sham	CKD
BUN (mmol/L)	8.51 ± 1.59	16.53 ± 4.40^**
Creatinine (mmol/L)	36.30 ± 5.93	99.38 ± 7.37^**
Serum albumin (g/L)	40.67 ± 3.22	33.48 ± 3.82^**
Urinary protein (mg/24 h)	5.56 ± 1.43	31.41 ± 10.82^**

BUN: blood urea nitrogen; CKD: chronic kidney disease. Serum BUN, creatinine, serum albumin, and urinary protein were evaluated in CKD versus sham-operated control rat. ( < 0.01 versus sham).