Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis

Figure 3

Effect of GYY4137 on collagen property in SHR. (a) Hydroxyproline concentrations in myocardium. (b-c) Quantification of collagen I and collagen III mRNA expression in myocardium was carried out with real-time RCR. (d) The amount of cross-linked and non-cross-linked collagen in the myocardium was evaluated as hydroxyproline content. (e) The ratio between cross-linked and non-cross-linked collagen was used as an index of the degree of collagen cross-linking. Plots represent mean ± SEM; . Statistical significance: , compared with WKY; , compared with SHR.

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