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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 709628, 17 pages
Review Article

Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity

1Department of Natural Resources Engineering and Management, University of Kurdistan, Hewler 44003, Iraq
2University College of Pharmacy, University of the Punjab, Lahore 54000, Pakistan
3Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
4Department of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan
5Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
6Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore 54000, Pakistan
7Key Laboratory of Biorheological Science and Technology, Chongqing University, Chongqing 400030, China

Received 12 December 2014; Accepted 13 March 2015

Academic Editor: Gabriele Saretzki

Copyright © 2015 Saima Jadoon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form include Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza sativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum, and Vitis vinifera. The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.