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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 709845, 13 pages
http://dx.doi.org/10.1155/2015/709845
Research Article

Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells

1Institute of Translational Medicine, Department of Ophthalmology, The First Hospital, Jilin University, Changchun 130001, China
2Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science and Veterinary Medicine, Jilin University, 5333 Xi’an Road, Changchun 130062, China

Received 22 December 2014; Revised 28 January 2015; Accepted 7 February 2015

Academic Editor: Zhenquan Jia

Copyright © 2015 Hongming Lv et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. Dalle-Donne, R. Rossi, R. Colombo, D. Giustarini, and A. Milzani, “Biomarkers of oxidative damage in human disease,” Clinical Chemistry, vol. 52, no. 4, pp. 601–623, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. L. H. Breimer, “Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: the role of DNA base damage,” Molecular Carcinogenesis, vol. 3, no. 4, pp. 188–197, 1990. View at Google Scholar · View at Scopus
  3. Q. Ma, “Role of Nrf2 in oxidative stress and toxicity,” Annual Review of Pharmacology and Toxicology, vol. 53, pp. 401–426, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. Y.-J. Surh, J. K. Kundu, H.-K. Na, and J.-S. Lee, “Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals,” The Journal of Nutrition, vol. 135, no. 12, supplement, pp. 2993S–3001S, 2005. View at Google Scholar · View at Scopus
  5. M. Kobayashi and M. Yamamoto, “Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation,” Antioxidants and Redox Signaling, vol. 7, no. 3-4, pp. 385–394, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. L. D. Deleve and N. Kaplowitz, “Importance and regulation of hepatic glutathione,” Seminars in Liver Disease, vol. 10, no. 4, pp. 251–266, 1990. View at Publisher · View at Google Scholar · View at Scopus
  7. D. P. Jones, “Redox potential of GSH/GSSG couple: assay and biological significance,” Methods in Enzymology, vol. 348, article 11, pp. 93–112, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. V. R. Biljak, L. Rumora, I. Čepelak et al., “Glutathione cycle in stable chronic obstructive pulmonary disease,” Cell Biochemistry and Function, vol. 28, no. 6, pp. 448–453, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. N. S. Gould, E. Min, S. Gauthier, R. J. Martin, and B. J. Day, “Lung glutathione adaptive responses to cigarette smoke exposure,” Respiratory Research, vol. 12, article 133, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. X. Shi and B. Zhou, “The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos,” Toxicological Sciences, vol. 115, no. 2, pp. 391–400, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. C. D. Ferris, S. R. Jaffrey, A. Sawa et al., “Haem oxygenase-1 prevents cell death by regulating cellular iron,” Nature Cell Biology, vol. 1, no. 3, pp. 152–157, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Mani, S. Khaghani, T. G. Mohammadi et al., “Activation of Nrf2-antioxidant response element mediated glutamate cysteine ligase expression in hepatoma cell line by homocysteine,” Hepatitis Monthly, vol. 13, no. 5, Article ID e8394, p. e8394, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Baird and A. T. Dinkova-Kostova, “The cytoprotective role of the Keap1-Nrf2 pathway,” Archives of Toxicology, vol. 85, no. 4, pp. 241–272, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. T. W. Kensler, N. Wakabayashi, and S. Biswal, “Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway,” Annual Review of Pharmacology and Toxicology, vol. 47, pp. 89–116, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. H.-C. Huang, T. Nguyen, and C. B. Pickett, “Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 23, pp. 12475–12480, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Numazawa, M. Ishikawa, A. Yoshida, S. Tanaka, and T. Yoshida, “Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress,” American Journal of Physiology—Cell Physiology, vol. 285, no. 2, pp. C334–C342, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Nakaso, H. Yano, Y. Fukuhara, T. Takeshima, K. Wada-Isoe, and K. Nakashima, “PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells,” FEBS Letters, vol. 546, no. 2-3, pp. 181–184, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. A.-N. T. Kong, E. Owuor, R. Yu et al., “Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE),” Drug Metabolism Reviews, vol. 33, no. 3-4, pp. 255–271, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. R. A. Dixon and C. L. Steele, “Flavonoids and isoflavonoids—a gold mine for metabolic engineering,” Trends in Plant Science, vol. 4, no. 10, pp. 394–400, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. M. G. L. Hertog, E. J. M. Feskens, P. C. H. Hollman, M. B. Katan, and D. Kromhout, “Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly study,” The Lancet, vol. 342, no. 8878, pp. 1007–1011, 1993. View at Publisher · View at Google Scholar · View at Scopus
  21. R. J. Williams, J. P. E. Spencer, and C. Rice-Evans, “Flavonoids: antioxidants or signalling molecules?” Free Radical Biology & Medicine, vol. 36, no. 7, pp. 838–849, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Hatano, H. Kagawa, T. Yasuhara, and T. Okuda, “Two new flavonoids and other constituents in licorice root: their relative astringency and radical scavenging effects,” Chemical and Pharmaceutical Bulletin, vol. 36, no. 6, pp. 2090–2097, 1988. View at Publisher · View at Google Scholar · View at Scopus
  23. H.-S. Kwon, J. H. Park, D. H. Kim et al., “Licochalcone a isolated from licorice suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice,” Journal of Molecular Medicine, vol. 86, no. 11, pp. 1287–1295, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Haraguchi, H. Ishikawa, K. Mizutani, Y. Tamura, and T. Kinoshita, “Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata,” Bioorganic & Medicinal Chemistry, vol. 6, no. 3, pp. 339–347, 1998. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Pi, Y. Bai, J. M. Reece et al., “Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2,” Free Radical Biology and Medicine, vol. 42, no. 12, pp. 1797–1806, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Reuter, S. C. Gupta, M. M. Chaturvedi, and B. B. Aggarwal, “Oxidative stress, inflammation, and cancer: how are they linked?” Free Radical Biology and Medicine, vol. 49, no. 11, pp. 1603–1616, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Oh, D.-H. Kim, J.-H. Cho, and Y.-C. Kim, “Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense,” Journal of Ethnopharmacology, vol. 95, no. 2-3, pp. 421–424, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Amoroso, A. D'Alessio, R. Sirabella, G. Di Renzo, and L. Annunziato, “Ca2+-independent caspase-3 but not Ca2+-dependent caspase-2 activation induced by oxidative stress leads to SH-SY5Y human neuroblastoma cell apoptosis,” Journal of Neuroscience Research, vol. 68, no. 4, pp. 454–462, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. M. S. Cooke, M. D. Evans, M. Dizdaroglu, and J. Lunec, “Oxidative DNA damage: mechanisms, mutation, and disease,” The FASEB Journal, vol. 17, no. 10, pp. 1195–1214, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. M. M. Cortes-Wanstreet, E. Giedzinski, C. L. Limoli, and U. Luderer, “Overexpression of glutamate-cysteine ligase protects human COV434 granulosa tumour cells against oxidative and γ-radiation-induced cell death,” Mutagenesis, vol. 24, no. 3, pp. 211–224, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. D. M. Townsend, K. D. Tew, and H. Tapiero, “The importance of glutathione in human disease,” Biomedicine and Pharmacotherapy, vol. 57, no. 3, pp. 145–155, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. M. G. Vani, K. J. S. Kumar, J.-W. Liao et al., “Antcin C from Antrodia cinnamomea protects liver cells against free radical-induced oxidative stress and apoptosis in vitro and in vivo through nrf2-dependent mechanism,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 296082, 17 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Bhattacharya, R. Gachhui, and P. C. Sil, “Hepatoprotective properties of kombucha tea against TBHP-induced oxidative stress via suppression of mitochondria dependent apoptosis,” Pathophysiology, vol. 18, no. 3, pp. 221–234, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. L. E. Otterbein, M. P. Soares, K. Yamashita, and F. H. Bach, “Heme oxygenase-1: unleashing the protective properties of heme,” Trends in Immunology, vol. 24, no. 8, pp. 449–455, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. R. K. Thimmulappa, C. Scollick, K. Traore et al., “Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide,” Biochemical and Biophysical Research Communications, vol. 351, no. 4, pp. 883–889, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. T. L. Adair-Kirk, J. J. Atkinson, G. L. Griffin et al., “Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells,” The American Journal of Respiratory Cell and Molecular Biology, vol. 39, no. 4, pp. 400–411, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. Y. P. Hwang, J. H. Choi, J. M. Choi, Y. C. Chung, and H. G. Jeong, “Protective mechanisms of anthocyanins from purple sweet potato against tert-butyl hydroperoxide-induced hepatotoxicity,” Food and Chemical Toxicology, vol. 49, no. 9, pp. 2081–2089, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. T. Nguyen, P. J. Sherratt, H.-C. Huang, C. S. Yang, and C. B. Pickett, “Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element: degradation of Nrf2 by the 26 S proteasome,” The Journal of Biological Chemistry, vol. 278, no. 7, pp. 4536–4541, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. L. M. Zipper and R. T. Mulcahy, “Inhibition of ERK and p38 MAP Kinases inhibits binding of Nrf2 and induction of GCS genes,” Biochemical and Biophysical Research Communications, vol. 278, no. 2, pp. 484–492, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. P. Gong, B. Hu, and A. I. Cederbaum, “Diallyl sulfide induces heme oxygenase-1 through MAPK pathway,” Archives of Biochemistry and Biophysics, vol. 432, no. 2, pp. 252–260, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. J. Kim, Y.-N. Cha, and Y.-J. Surh, “A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders,” Mutation Research, vol. 690, no. 1-2, pp. 12–23, 2010. View at Publisher · View at Google Scholar · View at Scopus