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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 723679, 8 pages
Research Article

Effects of Exercise Intensity on Postexercise Endothelial Function and Oxidative Stress

1Sport and Exercise Sciences Research Institute, Ulster University, Jordanstown, County Antrim BT37 0QB, UK
2Division of Clinical & Translational Sciences, Georgia Prevention Center, Georgia Regents University, 1120 15th Street HS-1707, Augusta, GA 30912, USA

Received 8 June 2015; Revised 5 August 2015; Accepted 9 August 2015

Academic Editor: Saeid Golbidi

Copyright © 2015 Conor McClean et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To measure endothelial function and oxidative stress immediately, 90 minutes, and three hours after exercise of varying intensities. Methods. Sixteen apparently healthy men completed three exercise bouts of treadmill running for 30 minutes at 55% (mild); 20 minutes at 75% (moderate); or 5 minutes at 100% (maximal) in random order. Brachial artery flow-mediated dilation (FMD) was assessed with venous blood samples drawn for measurement of endothelin-1 (ET-1), lipid hydroperoxides (LOOHs), and lipid soluble antioxidants. Results. LOOH increased immediately following moderate exercise (). ET-1 was higher immediately after exercise and 3 hours after exercise in the mild trial compared to maximal one (). Transient decreases were detected for / from baseline following maximal exercise, but it normalised at 3 hours after exercise (). Shear rate was higher immediately after exercise in the maximal trial compared to mild exercise (). No changes in baseline diameter, peak diameter, absolute change in diameter, or FMD were observed following any of the exercise trials (). Conclusions. Acute exercise at different intensities elicits varied effects on oxidative stress, shear rate, and ET-1 that do not appear to mediate changes in endothelial function measured by FMD.