Comparative Meta-Analysis of Transcriptomics Data during Cellular Senescence and In Vivo Tissue Ageing

Figure 2

Identification of (gender-independent) coregulated potential biomarkers of ageing in human postmitotic skeletal muscle and nervous tissues. Venn diagram comparing DEGs in skeletal muscle and nervous tissues of young and aged individuals ( value ≤ 0.05; FDR ≤ 0.1; FC > 1.2). In skeletal muscle (light green; 6 experiments analysed), the total number of differentially expressed genes during ageing was 1551, while 387 genes were found to be differentially expressed during ageing of the nervous tissue (light yellow; 1 experiment analysed). The intersection of the two groups contains 66 common DEGs; the identified “hub-genes” (GORevenge algorithm) are listed in descending order of their GO terms’ linkage number.