Comparative Meta-Analysis of Transcriptomics Data during Cellular Senescence and In Vivo Tissue Ageing

Figure 5

Differentially regulated human genes during cellular senescence and in vivo tissue ageing. (a) Venn diagram showing the differentially regulated genes ( value ≤ 0.05; FC ≥ 1.5) during cellular senescence and in vivo tissue ageing. The yellow circle represents the number of DEGs derived by the merging of five different datasets (experiments) of the cell-based transcriptomics data, while the blue circle represents the number of DEGs derived by the merging of seven different datasets (experiments) of in vivo tissue ageing transcriptomics. The overlapping “green” area indicates the number of DEGs that are common in both conditions. (b) Two-way hierarchical clustering analysis based on the expression profiles of the common differentially expressed genes. Each column represents the gene expression levels per dataset and each row denotes the corresponding gene. Red and dark-green colours indicate that the obtained values are greater than 1.5-fold or less than −1.5-fold, respectively; grey colour indicates statistically not significant changes or not expressed genes. Gene symbols are given in the left. HSCs-1: PBCD34⁺38⁻. HSCs-2: BMCD34⁺.

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