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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 750637, 12 pages
http://dx.doi.org/10.1155/2015/750637
Review Article

Oxidative Stress in Myopia

1Instituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Avenida del Seminario s/n, Moncada, 46313 Valencia, Spain
2FISABIO, Oftalmología Médica, Bifurcación Pío Baroja-general Aviles, S/N, 46015 Valencia, Spain

Received 6 January 2015; Revised 10 March 2015; Accepted 17 March 2015

Academic Editor: Cinzia Signorini

Copyright © 2015 Bosch-Morell Francisco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Y. Wong, P. J. Foster, J. Hee et al., “Prevalence and risk factors for refractive errors in adult Chinese in Singapore,” Investigative Ophthalmology and Visual Science, vol. 41, no. 9, pp. 2486–2494, 2000. View at Google Scholar · View at Scopus
  2. M. R. van Newkirk, “The Hong Kong Vision Study: a pilot assessment of visual impairment in adults,” Transactions of the American Ophthalmological Society, vol. 95, pp. 715–749, 1997. View at Google Scholar · View at Scopus
  3. E. C. Kim, I. G. Morgan, H. Kakizaki, S. Kang, and D. Jee, “Prevalence and risk factors for refractive errors: Korean National Health and Nutrition Examination Survey 2008–2011,” PLoS ONE, vol. 8, no. 11, Article ID e80361, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Krishnaiah, M. Srinivas, R. C. Khanna, and G. N. Rao, “Prevalence and risk factors for refractive errors in the South Indian adult population: the Andhra Pradesh Eye disease study,” Clinical Ophthalmology, vol. 3, no. 1, pp. 17–27, 2009. View at Google Scholar · View at Scopus
  5. A. Sawada, A. Tomidokoro, M. Araie, A. Iwase, T. Yamamoto, and Tajimi Study Group, “Refractive errors in an elderly Japanese population: the Tajimi study,” Ophthalmology, vol. 115, no. 2, pp. 363–370, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. J. H. Kempen, P. Mitchell, K. E. Lee et al., “The prevalence of refractive errors among adults in the United States, Western Europe, and Australia,” Archives of Ophthalmology, vol. 122, no. 4, pp. 495–505, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. C. W. Pan, Y. F. Zheng, T. Y. Wong et al., “Variation in prevalence of myopia between generations of migrant indians living in Singapore,” The American Journal of Ophthalmology, vol. 154, no. 2, pp. 376.e1–381.e1, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. R. I. Bloom, I. B. Friedman, and R. S. Chuck, “Increasing rates of myopia: the long view,” Current Opinion in Ophthalmology, vol. 21, no. 4, pp. 247–248, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. I. G. Morgan, K. Ohno-Matsui, and S.-M. Saw, “Myopia,” The Lancet, vol. 379, no. 9827, pp. 1739–1748, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. S.-M. Saw, G. Gazzard, E. C. Shin-Yen, and W.-H. Chua, “Myopia and associated pathological complications,” Ophthalmic and Physiological Optics, vol. 25, no. 5, pp. 381–391, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Zadnik, “It's the retina, stupid,” Optometry & Vision Science, vol. 78, no. 4, pp. 179–180, 2001. View at Google Scholar · View at Scopus
  12. C.-W. Pan, Y.-F. Zheng, A. R. Anuar et al., “Prevalence of refractive errors in a multiethnic Asian population: the singapore epidemiology of eye disease study,” Investigative Ophthalmology and Visual Science, vol. 54, no. 4, pp. 2590–2598, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. B. Dayan, A. Levin, Y. Morad et al., “The changing prevalence of myopia in young adults: a 13-year series of population-based prevalence surveys,” Investigative Ophthalmology & Visual Science, vol. 46, no. 8, pp. 2760–2765, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Vitale, R. D. Sperduto, and F. L. Ferris III, “Increased prevalence of myopia in the United States between 1971-1972 and 1999–2004,” Archives of Ophthalmology, vol. 127, no. 12, pp. 1632–1639, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. V. Koh, A. Yang, S. M. Saw et al., “Differences in prevalence of refractive errors in young Asian males in Singapore between 1996-1997 and 2009-2010,” Ophthalmic Epidemiology, vol. 21, no. 4, pp. 247–255, 2014. View at Publisher · View at Google Scholar
  16. B. S. Winkler, M. E. Boulton, J. D. Gottsch, and P. Sternberg, “Oxidative damage and age-related macular degeneration,” Molecular Vision, vol. 5, p. 32, 1999. View at Google Scholar · View at Scopus
  17. S. Beatty, H.-H. Koh, M. Phil, D. Henson, and M. Boulton, “The role of oxidative stress in the pathogenesis of age-related macular degeneration,” Survey of Ophthalmology, vol. 45, no. 2, pp. 115–134, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Wojciechowski, “Nature and nurture: the complex genetics of myopia and refractive error,” Clinical Genetics, vol. 79, no. 4, pp. 301–320, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. H.-J. Lin, L. Wan, Y. Tsai et al., “Sclera-related gene polymorphisms in high myopia,” Molecular Vision, vol. 15, pp. 1655–1663, 2009. View at Google Scholar · View at Scopus
  20. Y. Seko, H. Shimokawa, and T. Tokoro, “Expression of bFGF and TGF-β2 in experimental myopia in chicks,” Investigative Ophthalmology & Visual Science, vol. 36, no. 6, pp. 1183–1187, 1995. View at Google Scholar · View at Scopus
  21. Z.-H. Deng, J. Tan, S.-Z. Liu, S.-Z. Zhao, and J.-T. Wang, “The correlation between the regulation of recombinant human IGF-2 on eye growth and form-deprivation in guinea pig,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 248, no. 4, pp. 519–525, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Wakabayashi, Y. Ikuno, Y. Oshima, T. Hamasaki, and K. Nishida, “Aqueous concentrations of vascular endothelial growth factor in eyes with high myopia with and without choroidal neovascularization,” Journal of Ophthalmology, vol. 2013, Article ID 257381, 5 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. H.-M. Wu, B. Seet, E. P.-H. Yap, S.-M. Saw, T.-H. Lim, and K.-S. Chia, “Does education explain ethnic differences in myopia prevalence? A population-based study of young adult males in Singapore,” Optometry and Vision Science, vol. 78, no. 4, pp. 234–239, 2001. View at Google Scholar · View at Scopus
  24. E. B. Dunphy, M. R. Stoll, and S. H. King, “Myopia among american male graduate students,” American Journal of Ophthalmology, vol. 65, no. 4, pp. 518–521, 1968. View at Publisher · View at Google Scholar · View at Scopus
  25. D. O. Mutti, “Hereditary and environmental contributions to emmetropization and myopia,” Optometry & Vision Science, vol. 87, no. 4, pp. 255–259, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. D. R. Fredrick, “Myopia,” British Medical Journal, vol. 324, no. 7347, pp. 1195–1199, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Gwiazda, L. Hyman, M. Hussein et al., “A randomized clinical trial of progressive addition lenses versus single vision lenses on the progression of myopia in children,” Investigative Ophthalmology and Visual Science, vol. 44, no. 4, pp. 1492–1500, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Deng, J. Gwiazda, R. E. Manny et al., “Limited change in anisometropia and aniso-axial length over 13 years in myopic children enrolled in the correction of myopia evaluation trial,” Investigative Ophthalmology & Visual Science, vol. 55, no. 4, pp. 2097–2105, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. T. T. Norton and J. T. Siegwart Jr., “Animal models of emmetropization: matching axial length to the focal plane,” Journal of the American Optometric Association, vol. 66, no. 7, pp. 405–414, 1995. View at Google Scholar · View at Scopus
  30. X. Zhu, “Temporal integration of visual signals in lens compensation (a review),” Experimental Eye Research, vol. 114, pp. 69–76, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Tong, X. L. Huang, A. L. T. Koh, X. Zhang, D. T. H. Tan, and W.-H. Chua, “Atropine for the treatment of childhood myopia: effect on myopia progression after cessation of atropine,” Ophthalmology, vol. 116, no. 3, pp. 572–579, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. R. M. Siatkowski, S. A. Cotter, R. S. Crockett et al., “Two-year multicenter, randomized, double-masked, placebo-controlled, parallel safety and efficacy study of 2% pirenzepine ophthalmic gel in children with myopia,” Journal of AAPOS, vol. 12, no. 4, pp. 332–339, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. C. F. Wildsoet, “Neural pathways subserving negative lens-induced emmetropization in chicks—insights from selective lesions of the optic nerve and ciliary nerve,” Current Eye Research, vol. 27, no. 6, pp. 371–385, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. I. G. Morgan, “The biological basis of myopic refractive error,” Clinical and Experimental Optometry, vol. 86, no. 5, pp. 276–288, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. G. J. I. Elejalde, “Oxidative stress, diseases and antioxidant treatment,” Anales de Medicina Interna, vol. 18, no. 6, pp. 326–335, 2001. View at Google Scholar · View at Scopus
  36. A. Izzotti, A. Bagnis, and S. C. Saccà, “The role of oxidative stress in glaucoma,” Mutation Research—Reviews in Mutation Research, vol. 612, no. 2, pp. 105–114, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. H. Izuta, N. Matsunaga, M. Shimazawa, T. Sugiyama, T. Ikeda, and H. Hara, “Proliferative diabetic retinopathy and relations among antioxidant activity, oxidative stress, and VEGF in the vitreous body,” Molecular Vision, vol. 16, pp. 130–136, 2010. View at Google Scholar · View at Scopus
  38. W. T. Ham Jr., H. A. Mueller, J. J. Ruffolo Jr. et al., “Basic mechanisms underlying the production of photochemical lesions in the mammalian retina,” Current Eye Research, vol. 3, no. 1, pp. 165–174, 1984. View at Publisher · View at Google Scholar · View at Scopus
  39. W. Sickel, “Electrical and metabolic manifestations of receptor and higher-order neuron activity in vertebrate retina,” Advances in Experimental Medicine and Biology, vol. 24, no. 0, pp. 101–118, 1972. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Fukui and C. T. Moraes, “The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?” Trends in Neurosciences, vol. 31, no. 5, pp. 251–256, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. B. Frei, R. Stocker, and B. N. Ames, “Antioxidant defenses and lipid peroxidation in human blood plasma,” Proceedings of the National Academy of Sciences of the United States of America, vol. 85, no. 24, pp. 9748–9752, 1988. View at Publisher · View at Google Scholar · View at Scopus
  42. B. Kisic, D. Miric, L. Zoric, A. Ilic, and I. Dragojevic, “Antioxidant capacity of lenses with age-related cataract,” Oxidative Medicine and Cellular Longevity, vol. 2012, Article ID 467130, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Mérida, M. Sancho-Tello, M. Muriach, M. Miranda, A. Navea, and F. Bosch-Morell, “Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release,” Free Radical Research, vol. 47, no. 8, pp. 593–601, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. M. L. Chalasani, V. Radha, V. Gupta, N. Agarwal, D. Balasubramanian, and G. Swarup, “A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants,” Investigative Ophthalmology & Visual Science, vol. 48, no. 4, pp. 1607–1614, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. L. Ye, T. Yu, Y. Li et al., “Sulforaphane enhances the ability of human retinal pigment epithelial cell against oxidative stress, and its effect on gene expression profile evaluated by microarray analysis,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 413024, 13 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  46. D. R. Crawford, R. J. Lauzon, Y. Wang, J. E. Mazurkiewicz, G. P. Schools, and K. J. A. Davies, “16S mitochondrial ribosomal RNA degradation is associated with apoptosis,” Free Radical Biology and Medicine, vol. 22, no. 7, pp. 1295–1300, 1997. View at Publisher · View at Google Scholar · View at Scopus
  47. L. Bhatt, G. Groeger, K. McDermott, and T. G. Cotter, “Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system,” Molecular Vision, vol. 16, pp. 283–293, 2010. View at Google Scholar · View at Scopus
  48. S. Y. Li, Z. J. Fu, and A. C. Y. Lo, “Hypoxia-induced oxidative stress in ischemic retinopathy,” Oxidative Medicine and Cellular Longevity, vol. 2012, Article ID 426769, 426769 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. E. S. Avetisov and N. F. Savitskaya, “Some features of ocular microcirculation in myopia,” Annals of Ophthalmology, vol. 9, no. 10, pp. 1261–1264, 1977. View at Google Scholar · View at Scopus
  50. Y.-F. Shih, I.-H. Horng, C.-H. Yang, L. L.-K. Lin, Y. Peng, and P.-T. Hung, “Ocular pulse amplitude in myopia,” Journal of Ocular Pharmacology, vol. 7, no. 1, pp. 83–88, 1991. View at Publisher · View at Google Scholar · View at Scopus
  51. Y.-F. Shih, M. E. C. Fitzgerald, T. T. Norton, P. D. R. Gamlin, W. Hodos, and A. Reiner, “Reduction in choroidal blood flow occurs in chicks wearing goggles that induce eye growth toward myopia,” Current Eye Research, vol. 12, no. 3, pp. 219–227, 1993. View at Publisher · View at Google Scholar · View at Scopus
  52. J. M. McCord, “Superoxide dismutase: rationale for use in reperfusion injury and inflammation,” Journal of Free Radicals in Biology & Medicine, vol. 2, no. 5-6, pp. 307–310, 1986. View at Publisher · View at Google Scholar · View at Scopus
  53. J. Nourooz-Zadeh and P. Pereira, “F2 isoprostanes, potential specific markers of oxidative damage in human retina,” Ophthalmic Research, vol. 32, no. 4, pp. 133–137, 2000. View at Publisher · View at Google Scholar · View at Scopus
  54. F. J. Romero, F. Bosch-Morell, M. J. Romero et al., “Lipid peroxidation products and antioxidants in human disease,” Environmental Health Perspectives, vol. 106, no. 5, pp. 1229–1234, 1998. View at Publisher · View at Google Scholar · View at Scopus
  55. A. K. Junk, A. Mammis, S. I. Savitz et al., “Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 16, pp. 10659–10664, 2002. View at Publisher · View at Google Scholar · View at Scopus
  56. A. Y. Abramov, A. Scorziello, and M. R. Duchen, “Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation,” Journal of Neuroscience, vol. 27, no. 5, pp. 1129–1138, 2007. View at Publisher · View at Google Scholar · View at Scopus
  57. J. M. Rieger, A. R. Shah, and J. M. Gidday, “Ischemia-reperfusion injury of retinal endothelium by cyclooxygenase- and xanthine oxidase-derived superoxide,” Experimental Eye Research, vol. 74, no. 4, pp. 493–501, 2002. View at Publisher · View at Google Scholar · View at Scopus
  58. C. E. Berry and J. M. Hare, “Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications,” Journal of Physiology, vol. 555, no. 3, pp. 589–606, 2004. View at Publisher · View at Google Scholar · View at Scopus
  59. J. Matsuo, H. Oku, Y. Kanbara, T. Kobayashi, T. Sugiyama, and T. Ikeda, “Involvement of NADPH oxidase and protein kinase C in endothelin-1-induced superoxide production in retinal microvessels,” Experimental Eye Research, vol. 89, no. 5, pp. 693–699, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. U. Schönfelder, A. Hofer, M. Paul, and R. H. W. Funk, “In situ observation of living pericytes in rat retinal capillaries,” Microvascular Research, vol. 56, no. 1, pp. 22–29, 1998. View at Publisher · View at Google Scholar · View at Scopus
  61. G. L. Wang, B.-H. Jiang, E. A. Rue, and G. L. Semenza, “Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 12, pp. 5510–5514, 1995. View at Publisher · View at Google Scholar · View at Scopus
  62. P. A. Campochiaro, “Ocular neovascularization,” Journal of Molecular Medicine, vol. 91, no. 3, pp. 311–321, 2013. View at Publisher · View at Google Scholar · View at Scopus
  63. S. A. Vinores, W.-H. Xiao, S. Aslam et al., “Implication of the hypoxia response element of the Vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development,” Journal of Cellular Physiology, vol. 206, no. 3, pp. 749–758, 2006. View at Publisher · View at Google Scholar · View at Scopus
  64. R. Lima e Silva, J. Shen, S. F. Hackett et al., “The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization,” The FASEB Journal, vol. 21, no. 12, pp. 3219–3230, 2007. View at Publisher · View at Google Scholar · View at Scopus
  65. H. Zhang, D. Z. Qian, Y. S. Tan et al., “Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 50, pp. 19579–19586, 2008. View at Publisher · View at Google Scholar · View at Scopus
  66. T. Yoshida, H. Zhang, T. Iwase, J. Shen, G. L. Semenza, and P. A. Campochiaro, “Digoxin inhibits retinal ischemia-induced HIF-1α expression and ocular neovascularization,” The FASEB Journal, vol. 24, no. 6, pp. 1759–1767, 2010. View at Publisher · View at Google Scholar · View at Scopus
  67. H. Lu, C. L. Dalgard, A. Mohyeldin, T. McFate, A. S. Tait, and A. Verma, “Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1,” The Journal of Biological Chemistry, vol. 280, no. 51, pp. 41928–41939, 2005. View at Publisher · View at Google Scholar · View at Scopus
  68. A. Dong, B. Xie, J. Shen et al., “Oxidative stress promotes ocular neovascularization,” Journal of Cellular Physiology, vol. 219, no. 3, pp. 544–552, 2009. View at Publisher · View at Google Scholar · View at Scopus
  69. W. G. Kaelin Jr. and P. J. Ratcliffe, “Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway,” Molecular Cell, vol. 30, no. 4, pp. 393–402, 2008. View at Publisher · View at Google Scholar · View at Scopus
  70. A. C. R. Epstein, J. M. Gleadle, L. A. McNeill et al., “C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation,” Cell, vol. 107, no. 1, pp. 43–54, 2001. View at Publisher · View at Google Scholar · View at Scopus
  71. F. Simonelli, A. Nesti, M. Pensa et al., “Lipid peroxidation and human cataractogenesis in diabetes and severe myopia,” Experimental Eye Research, vol. 49, no. 2, pp. 181–187, 1989. View at Publisher · View at Google Scholar · View at Scopus
  72. T. Micelli-Ferrari, G. Vendemiale, I. Grattagliano et al., “Role of lipid peroxidation in the pathogenesis of myopic and senile cataract,” British Journal of Ophthalmology, vol. 80, no. 9, pp. 840–843, 1996. View at Publisher · View at Google Scholar · View at Scopus
  73. E. Altomare, G. Vendemiale, I. Grattagliano, P. Angelini, T. Micelli-Ferrari, and L. Cardia, “Human diabetic cataract: role of lipid peroxidation,” Diabete et Metabolisme, vol. 21, no. 3, pp. 173–179, 1995. View at Google Scholar · View at Scopus
  74. R. P. Bhatia, R. Rai, and G. R. K. Rao, “Role of malondialdehyde and superoxide dismutase in cataractogenesis,” Annals of Ophthalmology, vol. 38, no. 2, pp. 103–106, 2006. View at Publisher · View at Google Scholar · View at Scopus
  75. F. Bosch-Morell, A. Sanz, M. Díaz-Llopis, and F. J. Romero, “Lipid peroxidation products in human subretinal fluid,” Free Radical Biology and Medicine, vol. 20, no. 7, pp. 899–903, 1996. View at Publisher · View at Google Scholar · View at Scopus
  76. J. D. McNeil, O. W. Wiebkin, W. H. Betts, and L. G. Cleland, “Depolymerisation products of hyaluronic acid after exposure to oxygen-derived free radicals,” Annals of the Rheumatic Diseases, vol. 44, no. 11, pp. 780–789, 1985. View at Publisher · View at Google Scholar · View at Scopus
  77. N. Arimura, Y. Ki-I, T. Hashiguchi et al., “Intraocular expression and release of high-mobility group box 1 protein in retinal detachment,” Laboratory Investigation, vol. 89, no. 3, pp. 278–289, 2009. View at Publisher · View at Google Scholar · View at Scopus
  78. V. Zanon-Moreno, P. Marco-Ventura, A. Lleo-Perez et al., “Oxidative stress in primary open-angle glaucoma,” Journal of Glaucoma, vol. 17, no. 4, pp. 263–268, 2008. View at Publisher · View at Google Scholar · View at Scopus
  79. G. V. Shkrebets, “Biochemical parameters and prediction of the development of glaucoma in patients with progressive myopia,” Vestnik Oftalmologii, vol. 126, no. 5, pp. 17–19, 2010. View at Google Scholar · View at Scopus
  80. S. R. Powell, “The antioxidant properties of zinc,” Journal of Nutrition, vol. 130, no. 5, pp. 1447S–1454S, 2000. View at Google Scholar
  81. R. D. Jager, W. F. Mieler, and J. W. Miller, “Age-related macular degeneration,” The New England Journal of Medicine, vol. 358, no. 24, pp. 2544–2617, 2008. View at Publisher · View at Google Scholar · View at Scopus
  82. X. Huibi, H. Kaixun, G. Qiuhua, Z. Yushan, and H. Xiuxian, “Prevention of axial elongation in myopia by the trace element zinc,” Biological Trace Element Research, vol. 79, no. 1, pp. 39–47, 2001. View at Publisher · View at Google Scholar
  83. M. I. Vinetskaia and E. N. Iomdina, “Study of lacrimal fluid trace elements in several eye diseases,” Vestnik oftalmologii, vol. 110, no. 4, pp. 24–26, 1994. View at Google Scholar · View at Scopus
  84. H. Xu, K. Huang, Q. Gao, Z. Gao, and X. Han, “A study on the prevention and treatment of myopia with nacre on chicks,” Pharmacological Research, vol. 44, no. 1, pp. 1–6, 2001. View at Publisher · View at Google Scholar · View at Scopus
  85. B. Z. Silverstone, N. Syrkin, N. Algur, and D. Berson, “A metabolic aspect of high myopia,” Annals of Ophthalmology, vol. 17, no. 9, pp. 546–551, 1985. View at Google Scholar · View at Scopus
  86. B. Z. Silverstone, M. H. Seelenfreund, D. Berson et al., “Copper and zinc metabolism in high myopic patients with retinal detachment evaluation of the Cu/Zn ratio,” Metabolic, Pediatric, & Systemic Ophthalmology, vol. 9, no. 1, pp. 581–583, 1986. View at Google Scholar · View at Scopus
  87. Y. Shi, Y. Li, D. Zhang et al., “Exome sequencing identifies ZNF644 mutations in high myopia,” PLoS Genetics, vol. 7, no. 6, Article ID e1002084, 2011. View at Publisher · View at Google Scholar · View at Scopus
  88. K.-N. Tran-Viet, E. S. Germain, V. Soler et al., “Study of a US cohort supports the role of ZNF644 and high-grade myopia susceptibility,” Molecular Vision, vol. 18, pp. 937–944, 2012. View at Google Scholar · View at Scopus
  89. E. Jamieson and D. Lester, “The novel human p. I587V variant in the ZNF644 gene is unlikely to be the pathogenic cause of dominantly inherited high myopia in a Chinese patient,” Investigative Ophthalmology and Visual Science, vol. 53, no. 10, p. 6728, 2012. View at Publisher · View at Google Scholar · View at Scopus
  90. X. Xiang, T. Wang, P. Tong et al., “New ZNF644 mutations identified in patients with high myopia,” Molecular Vision, vol. 20, pp. 939–946, 2014. View at Google Scholar
  91. L. S. Einbond, K. A. Reynertson, X.-D. Luo, M. J. Basile, and E. J. Kennelly, “Anthocyanin antioxidants from edible fruits,” Food Chemistry, vol. 84, no. 1, pp. 23–28, 2004. View at Publisher · View at Google Scholar · View at Scopus
  92. K. Kamiya, H. Kobashi, K. Fujiwara, W. Ando, and K. Shimizu, “Effect of fermented bilberry extracts on visual outcomes in eyes with myopia: a prospective, randomized, placebo-controlled study,” Journal of Ocular Pharmacology and Therapeutics, vol. 29, no. 3, pp. 356–359, 2013. View at Publisher · View at Google Scholar · View at Scopus
  93. J. Lee, H. K. Lee, C. Y. Kim et al., “Purified high-dose anthocyanoside oligomer administration improves nocturnal vision and clinical symptoms in myopia subjects,” British Journal of Nutrition, vol. 93, no. 6, pp. 895–899, 2005. View at Publisher · View at Google Scholar · View at Scopus
  94. I. M. Goldstein, P. Ostwald, and S. Roth, “Nitric oxide: a review of its role in retinal function and disease,” Vision Research, vol. 36, no. 18, pp. 2979–2994, 1996. View at Publisher · View at Google Scholar · View at Scopus
  95. D. Modun, D. Giustarini, and D. Tsikas, “Nitric oxide-related oxidative stress and redox status in health and disease,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 129651, 3 pages, 2014. View at Publisher · View at Google Scholar
  96. G. C. Y. Chiou, “Review: effects of nitric oxide on eye diseases and their treatment,” Journal of Ocular Pharmacology and Therapeutics, vol. 17, no. 2, pp. 189–198, 2001. View at Publisher · View at Google Scholar · View at Scopus
  97. T. Fujikado, Y. Kawasaki, J. Fujii et al., “The effect of nitric oxide synthase inhibitor on form-deprivation myopia,” Current Eye Research, vol. 16, no. 10, pp. 992–996, 1997. View at Publisher · View at Google Scholar · View at Scopus
  98. T. Fujikado, K. Tsujikawa, M. Tamura, J. Hosohata, Y. Kawasaki, and Y. Tano, “Effect of a nitric oxide synthase inhibitor on lens-induced myopia,” Ophthalmic Research, vol. 33, no. 2, pp. 75–79, 2001. View at Publisher · View at Google Scholar · View at Scopus
  99. D. L. Nickla, E. Wilken, G. Lytle, S. Yom, and J. Mertz, “Inhibiting the transient choroidal thickening response using the nitric oxide synthase inhibitor l-NAME prevents the ameliorative effects of visual experience on ocular growth in two different visual paradigms,” Experimental Eye Research, vol. 83, no. 2, pp. 456–464, 2006. View at Publisher · View at Google Scholar · View at Scopus
  100. F. Fang, M. Pan, T. Yan et al., “The role of cGMP in ocular growth and the development of form-deprivation myopia in guinea pigs,” Investigative Ophthalmology & Visual Science, vol. 54, no. 13, pp. 7887–7902, 2013. View at Publisher · View at Google Scholar · View at Scopus
  101. E. Kosenko, M. Llansola, C. Montoliu et al., “Glutamine synthetase activity and glutamine content in brain: Modulation by NMDA receptors and nitric oxide,” Neurochemistry International, vol. 43, no. 4-5, pp. 493–499, 2003. View at Publisher · View at Google Scholar · View at Scopus
  102. S. Fujii, S. Honda, Y. Sekiya, M. Yamasaki, M. Yamamoto, and K. Saijoh, “Differential expression of nitric oxide synthase isoforms in form-deprived chick eyes,” Current Eye Research, vol. 17, no. 6, pp. 586–593, 1998. View at Publisher · View at Google Scholar · View at Scopus
  103. D. L. Nickla, P. Damyanova, and G. Lytle, “Inhibiting the neuronal isoform of nitric oxide synthase has similar effects on the compensatory choroidal and axial responses to myopic defocus in chicks as does the non-specific inhibitor l-NAME,” Experimental Eye Research, vol. 88, no. 6, pp. 1092–1099, 2009. View at Publisher · View at Google Scholar · View at Scopus
  104. A. W. Siu, G. G. Ortiz, G. Benitez-King, C. H. To, and R. J. Reiter, “Effects of melatonin on the nitric oxide treated retina,” British Journal of Ophthalmology, vol. 88, no. 8, pp. 1078–1081, 2004. View at Publisher · View at Google Scholar · View at Scopus
  105. H. Ríos, J. J. López-Costa, N. S. Fosser, A. Brusco, and J. P. Saavedra, “Development of nitric oxide neurons in the chick embryo retina,” Developmental Brain Research, vol. 120, no. 1, pp. 17–25, 2000. View at Publisher · View at Google Scholar · View at Scopus
  106. M. Feldkaemper and F. Schaeffel, “An updated view on the role of dopamine in myopia,” Experimental Eye Research, vol. 114, pp. 106–119, 2013. View at Publisher · View at Google Scholar · View at Scopus
  107. M. Nebbioso, A. M. Plateroti, B. Pucci, and N. Pescosolido, “Role of the dopaminergic system in the development of myopia in children and adolescents,” Journal of Child Neurology, vol. 29, no. 12, pp. 1739–1746, 2014. View at Publisher · View at Google Scholar
  108. M. Teves, Q. Shi, W. K. Stell, and D. Eng, “The role of cell-cell coupling in myopia development and light adaptation,” Investigative Ophthalmology & Visual Science, vol. 55, no. 5, p. 3036, 2014. View at Google Scholar
  109. D. L. Nickla, L. Lee, and K. Totonelly, “Nitric oxide synthase inhibitors prevent the growth-inhibiting effects of quinpirole,” Optometry and Vision Science, vol. 90, no. 11, pp. 1167–1175, 2013. View at Publisher · View at Google Scholar · View at Scopus
  110. R. A. Stone, T. Lin, A. M. Laties, and P. M. Iuvone, “Retinal dopamine and form-deprivation myopia,” Proceedings of the National Academy of Sciences of the United States of America, vol. 86, no. 2, pp. 704–706, 1989. View at Publisher · View at Google Scholar · View at Scopus
  111. B. L. D. S. Andrade da Costa and J. N. Hokoç, “Coexistence of GAD-65 and GAD-67 with tyrosine hydroxylase and nitric oxide synthase in amacrine and interplexiform cells of the primate, Cebus apella,” Visual Neuroscience, vol. 20, no. 2, pp. 153–163, 2003. View at Publisher · View at Google Scholar · View at Scopus
  112. S. A. Bloomfield and B. Völgyi, “The diverse functional roles and regulation of neuronal gap junctions in the retina,” Nature Reviews Neuroscience, vol. 10, no. 7, pp. 495–506, 2009. View at Publisher · View at Google Scholar · View at Scopus
  113. J. Ara, S. Przedborski, A. B. Naini et al., “Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP),” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 13, pp. 7659–7663, 1998. View at Publisher · View at Google Scholar · View at Scopus
  114. U. Landmesser, S. Dikalov, S. R. Price et al., “Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension,” The Journal of Clinical Investigation, vol. 111, no. 8, pp. 1201–1209, 2003. View at Publisher · View at Google Scholar · View at Scopus
  115. T. Shang, S. Kotamraju, S. V. Kalivendi, C. J. Hillard, and B. Kalyanaraman, “1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide,” The Journal of Biological Chemistry, vol. 279, no. 18, pp. 19099–19112, 2004. View at Publisher · View at Google Scholar · View at Scopus
  116. R. Heller, A. Unbehaun, B. Schellenberg, B. Mayer, G. Werner-Felmayer, and E. R. Werner, “L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin,” The Journal of Biological Chemistry, vol. 276, no. 1, pp. 40–47, 2001. View at Publisher · View at Google Scholar · View at Scopus
  117. S. P. Ayalasomayajula and U. B. Kompella, “Induction of vascular endothelial growth factor by 4-hydroxynonenal and its prevention by glutathione precursors in retinal pigment epithelial cells,” European Journal of Pharmacology, vol. 449, no. 3, pp. 213–220, 2002. View at Publisher · View at Google Scholar · View at Scopus
  118. M. Hollborn, K. Jahn, G. A. Limb, L. Kohen, P. Wiedemann, and A. Bringmann, “Characterization of the basic fibroblast growth factor-evoked proliferation of the human Müller cell line, MIO-M1,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 242, no. 5, pp. 414–422, 2004. View at Publisher · View at Google Scholar · View at Scopus
  119. S. Machida, M. Tanaka, T. Ishii, K. Ohtaka, T. Takahashi, and Y. Tazawa, “Neuroprotective effect of hepatocyte growth factor against photoreceptor degeneration in rats,” Investigative Ophthalmology and Visual Science, vol. 45, no. 11, pp. 4174–4182, 2004. View at Publisher · View at Google Scholar · View at Scopus
  120. L. Tönges, T. Ostendorf, F. Lamballe et al., “Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo,” Journal of Neurochemistry, vol. 117, no. 5, pp. 892–903, 2011. View at Publisher · View at Google Scholar · View at Scopus
  121. B. Vasir, P. Reitz, G. Xu, A. Sharma, S. Bonner-Weir, and G. C. Weir, “Effects of diabetes and hypoxia on gene markers of angiogenesis (HGF, cMET, uPA and uPAR, TGF-α, TGF-β, bFGF and Vimentin) in cultured and transplanted rat islets,” Diabetologia, vol. 43, no. 6, pp. 763–772, 2000. View at Publisher · View at Google Scholar · View at Scopus
  122. A. C. Clermont, M. Cahill, H. Salti et al., “Hepatocyte growth factor induces retinal vascular permeability via MAP-kinase and PI-3 kinase without altering retinal hemodynamics,” Investigative Ophthalmology and Visual Science, vol. 47, no. 6, pp. 2701–2708, 2006. View at Publisher · View at Google Scholar · View at Scopus
  123. K. Makondo, K. Kimura, N. Kitamura et al., “Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca2+- and phosphoinositide 3-kinase/Akt-dependent phosphorylation in aortic endothelial cells,” Biochemical Journal, vol. 374, no. 1, pp. 63–69, 2003. View at Publisher · View at Google Scholar · View at Scopus
  124. A. Uruno, A. Sugawara, H. Kanatsuka et al., “Hepatocyte growth factor stimulates nitric oxide production through endothelial nitric oxide synthase activation by the phosphoinositide 3-kinase/Akt pathway and possibly by mitogen-activated protein kinase kinase in vascular endothelial cells,” Hypertension Research, vol. 27, no. 11, pp. 887–895, 2004. View at Publisher · View at Google Scholar · View at Scopus
  125. C. C. Khor, Q. Fan, L.-K. Goh et al., “Hepatocyte growth factor and retinal arteriolar diameter in Singapore Chinese,” Ophthalmology, vol. 117, no. 5, pp. 939–945, 2010. View at Publisher · View at Google Scholar · View at Scopus
  126. S. Tsuboi, “Elevation of glutathione level in rat hepatocytes by hepatocyte growth factor via induction of gamma-glutamylcysteine synthetase,” Journal of Biochemistry, vol. 126, no. 5, pp. 815–820, 1999. View at Publisher · View at Google Scholar · View at Scopus
  127. M. Jin, Y. Chen, S. He, S. J. Ryan, and D. R. Hinton, “Hepatocyte growth factor and its role in the pathogenesis of retinal detachment,” Investigative Ophthalmology & Visual Science, vol. 45, no. 1, pp. 323–329, 2004. View at Publisher · View at Google Scholar · View at Scopus
  128. R. Kannan, M. Jin, M. A. Gamulescu, and D. R. Hinton, “Ceramide-induced apoptosis: role of catalase and hepatocyte growth factor,” Free Radical Biology and Medicine, vol. 37, no. 2, pp. 166–175, 2004. View at Publisher · View at Google Scholar · View at Scopus
  129. M. Jin, J. Yaung, R. Kannan, S. He, S. J. Ryan, and D. R. Hinton, “Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion,” Investigative Ophthalmology & Visual Science, vol. 46, no. 11, pp. 4311–4319, 2005. View at Publisher · View at Google Scholar · View at Scopus