Effects of Ezetimibe/Simvastatin and Rosuvastatin on Oxidative Stress in Diabetic Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Table 3
Metabolic characteristics. Biochemical parameters are reported for each treatment group before and after intervention.
Placebo
Ezetimibe/simvastatin
Rosuvastatin
Baseline
Final
Baseline
Final
Baseline
Final
Fasting plasma glucose (mg/dL)
186.4 ± 14.48
150.2 ± 11.20
0.004
146.64 ± 9.92
152.6 ± 14.00
0.620
192.04 ± 12.73
179.2 ± 15.20
0.520
Urea (mg/dL)
29.5 ± 2.1
28.9 ± 2.2
0.520
30.03 ± 1.51
32.5 ± 1.9
0.280
31.22 ± 2.27
28.6 ± 2.2
0.300
Creatinine (mg/dL)
0.79 ± 0.04
0.84 ± 0.05
0.180
0.82 ± 0.04
0.85 ± 0.05
0.570
0.84 ± 0.04
0.80 ± 0.04
0.320
AST (U/L)
21.9 ± 1.89
21.8 ± 1.4
0.820
24.63 ± 0.99
27.1 ± 2.5
0.270
27.8 ± 1.91
26.7 ± 1.2
0.700
ALT (U/L)
20.2 ± 1.43
20.5 ± 1.9
0.990
28.57 ± 3.26
28.4 ± 3.1
0.570
31.22 ± 2.47
30.3 ± 2.4
0.870
GGT (U/L)
34.73 ± 6.49
39.4 ± 8.6
0.270
39.83 ± 9.04
33.7 ± 3.7
0.780
44.33 ± 6.93
43.9 ± 7.7
0.260
Bilirubin (mg/dL)
0.70 ± 0.06
0.56 ± 0.05
0.052
0.61 ± 0.04
0.64 ± 0.06
0.800
0.83 ± 0.05
0.65 ± 0.07
0.020
Cholesterol (mg/dL)
211.43 ± 11.73
202.3 ± 8
0.610
210.56 ± 9.94
129.3 ± 9.7
0.001
217.2 ± 8.04
142.7 ± 8.8
0.001
LDL (mg/dL)
126.68 ± 8.76
109.6 ± 7.8
0.010
117.45 ± 7.16
61.7 ± 6.1
0.001
133.56 ± 7.96
75 ± 8.1
0.001
HDL (mg/dL)
36.95 ± 2.61
39.7 ± 2.5
0.470
36.23 ± 2.06
32.7 ± 2.1
0.090
36.79 ± 1.91
36.5 ± 2.3
0.360
Triglycerides (mg/dL)
240.13 ± 27.41
242.4
0.590
234.63 ± 49.96
161.9 ± 21.2
0.055
220.6 ± 24.49
168.4 ± 24.4
0.003
CK (U/L)
82.21 ± 13.78
82.8 ± 10.3
0.930
95.92 ± 14.4
86.4 ± 8.3
0.460
114.93 ± 18.44
157.3 ± 35.1
0.190
HBA1C % (mmol/mol)
8.8 (73) ± 0.36
9.2 (77) ± 0.5
0.260
7.8 (62) ± 0.32
8.1 (65) ± 0.4
0.250
9.0 (75) ± 0.40
9.4 (79) ± 0.4
0.090
Mean ± SEM versus placebo; versus placebo; versus placebo; versus ezetimibe/simvastatin (Mann-Whitney’s ). ALT, alanine transaminase; AST, aspartate transaminase; CPK, creatine kinase; HBA1C, glycated hemoglobin; HDL, high-density lipoproteins; GGT, gamma glutamyl transferase; LDL, low-density lipoproteins.
