Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2015 (2015), Article ID 762192, 8 pages
http://dx.doi.org/10.1155/2015/762192
Research Article

Dry Olive Leaf Extract Counteracts L-Thyroxine-Induced Genotoxicity in Human Peripheral Blood Leukocytes In Vitro

1Department of Biology and Human Genetics, Institute of Physiology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia
2Department of Biology, Faculty of Veterinary Medicine, University of Belgrade, Bulevar Oslobođenja 18, 11000 Belgrade, Serbia
3The Laboratory for Radiobiology and Molecular Genetics, Institute for Nuclear Research “Vinča”, University of Belgrade, Mike Petrovića Alasa 12-14, 11000 Belgrade, Serbia
4Biomedical Research, R&D Institute, Galenika a.d., Pasterova 2, 11000 Belgrade, Serbia

Received 8 December 2014; Accepted 8 February 2015

Academic Editor: Janusz Gebicki

Copyright © 2015 Dijana Žukovec Topalović et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Nunez, “Hormone metabolisms in cardiovascular toxicology,” in Endocrine and Hormonal Toxicology, P. W. Harvey, K. C. Rush, and A. Cockburn, Eds., John Wiley & Sons, Chichester, UK, 1999. View at Google Scholar
  2. P. Venditti, R. De Rosa, and S. Di Meo, “Effect of thyroid state on H2O2 production by rat liver mitochondria,” Molecular and Cellular Endocrinology, vol. 205, no. 1-2, pp. 185–192, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. V. Fernández, G. Tapia, P. Varela, P. Romanque, D. Cartier-Ugarte, and L. A. Videla, “Thyroid hormone-induced oxidative stress in rodents and humans: a comparative view and relation to redox regulation of gene expression,” Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, vol. 142, no. 3-4, pp. 231–239, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. U. M. Schmidt-Ott and D. D. Ascheim, “Thyroid hormone and heart failure,” Current Heart Failure Reports, vol. 3, no. 3, pp. 114–119, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. A. K. Chandra, S. Sinha, and S. R. Choudhury, “Thyroxine induced stress and its possible prevention by catechin,” Indian Journal of Experimental Biology, vol. 48, no. 6, pp. 559–565, 2010. View at Google Scholar · View at Scopus
  6. I. Villanueva, C. Alva-Sánchez, and J. Pacheco-Rosado, “The role of thyroid hormones as inductors of oxidative stress and neurodegeneration,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 218145, 15 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Venditti and S. di Meo, “Thyroid hormone-induced oxidative stress,” Cellular and Molecular Life Sciences, vol. 63, no. 4, pp. 414–434, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Tapia, P. Cornejo, V. Fernández, and L. A. Videla, “Protein oxidation in thyroid hormone-induced liver oxidative stress: relation to lipid peroxidation,” Toxicology Letters, vol. 106, no. 2-3, pp. 209–214, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. C. H. Magsino Jr., W. Hamouda, H. Ghanim, R. Browne, A. Aljada, and P. Dandona, “Effect of triiodothyronine on reactive oxygen species generation by leukocytes, indices of oxidative damage, and antioxidant reserve,” Metabolism, vol. 49, no. 6, pp. 799–803, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Moldeus, M. Nordenskjold, G. Bolcsfoldi, A. Eiche, U. Haglund, and B. Lambert, “Genetic toxicity of dopamine,” Mutation Research, vol. 124, no. 1, pp. 9–24, 1983. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Djelić and D. Anderson, “The effect of the antioxidant catalase on oestrogens, triiodothyronine, and noradrenaline in the Comet assay,” Teratogenesis, Carcinogenesis, and Mutagenesis, vol. 2, no. 2, pp. 69–81, 2003. View at Google Scholar · View at Scopus
  12. M. M. Dobrzyńska, A. Baumgartner, and D. Anderson, “Antioxidants modulate thyroid hormone- and noradrenaline-induced DNA damage in human sperm,” Mutagenesis, vol. 19, no. 4, pp. 325–330, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Khansari, Y. Shakiba, and M. Mahmoudi, “Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer,” Recent Patents on Inflammation and Allergy Drug Discovery, vol. 3, no. 1, pp. 73–80, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. R. M. Ortega, “Importance of functional foods in the Mediterranean diet,” Public Health Nutrition, vol. 9, no. 8, pp. 1136–1140, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Vasto, A. Barera, C. Rizzo, M. Di Carlo, C. Caruso, and G. Panotopoulos, “Mediterranean diet and longevity: an example of nutraceuticals?” Current Vascular Pharmacology, vol. 12, no. 5, pp. 735–738, 2014. View at Publisher · View at Google Scholar
  16. S. Vasto, S. Buscemi, A. Barera, M. Di Carlo, G. Accardi, and C. Caruso, “Mediterranean diet and healthy ageing: a sicilian perspective,” Gerontology, vol. 60, no. 6, pp. 508–518, 2014. View at Publisher · View at Google Scholar
  17. M.-J. Oliveras-López, J. J. M. Molina, M. V. Mir, E. F. Rey, F. Martín, and H. L.-G. de la Serrana, “Extra virgin olive oil (EVOO) consumption and antioxidant status in healthy institutionalized elderly humans,” Archives of Gerontology and Geriatrics, vol. 57, no. 2, pp. 234–242, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Zbakh and A. El Abbassi, “Potential use of olive mill wastewater in the preparation of functional beverages: a review,” Journal of Functional Foods, vol. 4, no. 1, pp. 53–65, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Silva, L. Gomes, F. Leitão, A. V. Coelho, and L. V. Boas, “Phenolic compounds and antioxidant activity of Olea europaea L. Fruits and leaves,” Food Science and Technology International, vol. 12, no. 5, pp. 385–395, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. S. N. El and S. Karakaya, “Olive tree (Olea europaea) leaves: potential beneficial effects on human health,” Nutrition Reviews, vol. 67, no. 11, pp. 632–638, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. D. Dekanski, S. Janićijević-Hudomal, V. Tadić, G. Marković, I. Arsić, and D. M. Mitrović, “Phytochemical analysis and gastroprotective activity of an olive leaf extract,” Journal of the Serbian Chemical Society, vol. 74, no. 4, pp. 367–377, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. I. Samet, J. Han, L. Jlaiel, S. Sayadi, and H. Isoda, “Olive (Olea europaea) leaf extract induces apoptosis and monocyte/macrophage differentiation in human chronic myelogenous leukemia K562 cells: insight into the underlying mechanism,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 927619, 16 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. O. Benavente-García, J. Castillo, J. Lorente, A. Ortuño, and J. A. Del Rio, “Antioxidant activity of phenolics extracted from Olea europaea L. leaves,” Food Chemistry, vol. 68, no. 4, pp. 457–462, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. M. de Bock, E. B. Thorstensen, J. G. B. Derraik, H. V. Henderson, P. L. Hofman, and W. S. Cutfield, “Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract,” Molecular Nutrition and Food Research, vol. 57, no. 11, pp. 2079–2085, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. I. Hassen, H. Casabianca, and K. Hosni, “Biological activities of the natural antioxidant oleuropein: exceeding the expectation—a mini-review,” Journal of Functional Foods, 2014. View at Publisher · View at Google Scholar
  26. D. Dekanski, V. Selaković, V. Piperski, Ž. Radulović, A. Korenić, and L. Radenović, “Protective effect of olive leaf extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in Mongolian gerbils,” Phytomedicine, vol. 18, no. 13, pp. 1137–1143, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. D. Dekanski, S. Ristić, and D. M. Mitrović, “Antioxidant effect of dry olive (Olea europaea L.) leaf extract on ethanol-induced gastric lesions in rats,” Mediterranean Journal of Nutrition and Metabolism, vol. 2, no. 3, pp. 205–211, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. D. Dekanski, S. Janićijević-Hudomal, S. Ristić et al., “Attenuation of cold restraint stress-induced gastric lesions by an olive leaf extract,” General Physiology and Biophysics, vol. 28, pp. 135–142, 2009. View at Google Scholar · View at Scopus
  29. D. Dekanski, N. Mihailović-Stanojević, J. Grujić Milanović, Đ. Jovović, and Z. Miloradović, “Effects of high dose olive leaf extract on haemodynamic and oxidative stress parameters in normotensive and spontaneously hypertensive rats,” Journal of the Serbian Chemical Society, vol. 79, no. 9, pp. 1085–1097, 2014. View at Publisher · View at Google Scholar
  30. J. Çoban, S. Öztezcan, S. Doğru-Abbasoğlu, I. Bingül, K. Yeşil-Mizrak, and M. Uysal, “Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats,” Geriatrics & Gerontology International, vol. 14, no. 4, pp. 996–1002, 2014. View at Publisher · View at Google Scholar
  31. R. Fabiani, P. Rosignoli, A. De Bartolomeo et al., “Oxidative DNA damage is prevented by extracts of olive oil, hydroxytyrosol, and other olive phenolic compounds in human blood mononuclear cells and HL60 cells,” The Journal of Nutrition, vol. 138, no. 8, pp. 1411–1416, 2008. View at Google Scholar · View at Scopus
  32. J. Anter, Z. Fernández-Bedmar, M. Villatoro-Pulido et al., “A pilot study on the DNA-protective, cytotoxic, and apoptosis-inducing properties of olive-leaf extracts,” Mutation Research—Genetic Toxicology and Environmental Mutagenesis, vol. 723, no. 2, pp. 165–170, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. H. Türkez and B. Toǧar, “Olive (Olea europaea L.) leaf extract counteracts genotoxicity and oxidative stress of permethrin in human lymphocytes,” The Journal of Toxicological Sciences, vol. 36, no. 5, pp. 531–537, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Čabarkapa, L. Živković, D. Žukovec et al., “Protective effect of dry olive leaf extract in adrenaline induced DNA damage evaluated using in vitro comet assay with human peripheral leukocytes,” Toxicology in Vitro, vol. 28, no. 3, pp. 451–456, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. E. Cemeli, A. Baumgartner, and D. Anderson, “Antioxidants and the Comet assay,” Mutation Research, vol. 681, no. 1, pp. 51–67, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. N. Djelić, D. Djelić, B. Spremo-Potparević et al., “Lack of clastogenic effects of L-thyroxine in whole-blood cultured human lymphocytes,” Genetics and Molecular Biology, vol. 30, no. 4, pp. 1144–1149, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Lee-Huang, L. Zhang, P. L. Huang, Y.-T. Chang, and P. L. Huang, “Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment,” Biochemical and Biophysical Research Communications, vol. 307, no. 4, pp. 1029–1037, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. R. Fares, S. Bazzi, S. E. Baydoun, and R. M. Abdel-Massih, “The antioxidant and anti-proliferative activity of the lebanese Olea europaea extract,” Plant Foods for Human Nutrition, vol. 66, no. 1, pp. 58–63, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. D. Anderson, T.-W. Yu, B. J. Phillips, and P. Schmezer, “The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay,” Mutation Research, vol. 307, no. 1, pp. 261–271, 1994. View at Publisher · View at Google Scholar · View at Scopus
  40. N. P. Singh, M. T. McCoy, R. R. Tice, and E. L. Schneider, “A simple technique for quantitation of low levels of DNA damage in individual cells,” Experimental Cell Research, vol. 175, no. 1, pp. 184–191, 1988. View at Publisher · View at Google Scholar · View at Scopus
  41. N. P. Singh, “Apoptosis assessment by the DNA diffusion assay,” Methods in Molecular Medicine, vol. 111, pp. 55–67, 2005. View at Google Scholar · View at Scopus
  42. N. Djelić, I. Nešić, Z. Stanimirović, and S. Jovanović, “Evaluation of the genotoxic effects of thyroxine using in vivo cytogenetic test on Swiss albino mice,” Acta Veterinaria, vol. 57, no. 5-6, pp. 487–495, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. P. Venditti, M. Balestrieri, S. di Meo, and T. de Leo, “Effect of thyroid state on lipid peroxidation, antioxidant defences, and susceptibility to oxidative stress in rat tissues,” Journal of Endocrinology, vol. 155, no. 1, pp. 151–157, 1997. View at Publisher · View at Google Scholar · View at Scopus
  44. D. K. Sahoo, A. Roy, and G. B. N. Chainy, “Protective effects of vitamin E and curcumin on l-thyroxine-induced rat testicular oxidative stress,” Chemico-Biological Interactions, vol. 176, no. 2-3, pp. 121–128, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. I. I. Abo Ghanema and K. M. Sadek, “Olive leaves extract restored the antioxidant perturbations in red blood cells hemolysate in streptozotocin induced diabetic rats,” World Academy of Science, Engineering & Technology, vol. 64, pp. 159–165, 2012. View at Google Scholar
  46. M. P. Mattson, “Hormesis defined,” Ageing Research Reviews, vol. 7, no. 1, pp. 1–7, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. V. Calabrese, C. Cornelius, A. Trovato-Salinaro et al., “The hormetic role of dietary antioxidants in free radical-related diseases,” Current Pharmaceutical Design, vol. 16, no. 7, pp. 877–883, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. O.-H. Lee and B.-Y. Lee, “Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract,” Bioresource Technology, vol. 101, no. 10, pp. 3751–3754, 2010. View at Publisher · View at Google Scholar · View at Scopus