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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 769739, 8 pages
http://dx.doi.org/10.1155/2015/769739
Research Article

Serum Ferritin Is Associated with Metabolic Syndrome and Red Meat Consumption

1Programa de Investigación de Excelencia Interdisciplinaria en Envejecimiento Saludable (PIEI-ES), Universidad de Talca, 3460000 Talca, Chile
2Centro de Nutrición Molecular y Enfermedades Crónicas, Pontificia Universidad Católica de Chile, Casilla 114-D, 8331150 Santiago, Chile
3Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile, 8330024 Santiago, Chile
4Departamento de Salud Pública, Facultad de Medicina, Pontificia Universidad Católica de Chile, 8330024 Santiago, Chile
5Laboratorio de Hemostasia, Facultad de Medicina, Pontificia Universidad Católica de Chile, 8330024 Santiago, Chile

Received 28 November 2014; Accepted 4 February 2015

Academic Editor: Xinchun Pi

Copyright © 2015 Avila Felipe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and Aims. Hyperferritinemia has been related with a wide spectrum of pathologies, including diabetes, cardiovascular disease, neurodegenerative disorders, and metabolic syndrome. The aim of this study was to investigate the association between hyperferritinemia and iron consumption. Methods and Results. Serum ferritin concentration was evaluated in 66 presumed healthy men, along with other clinical and biochemical markers of chronic diseases. A three-day food questionnaire was applied for nutrition information. Hyperferritinemia was a condition found in 13.4% of the volunteers analyzed. Significant correlations were found between serum ferritin concentration and metabolic syndrome parameters (HDL cholesterol, triglycerides, and fasting glucose) as well as an increase of the serum ferritin mean value with the number of risk factors of metabolic syndrome. Also, oxidative stress markers (carbonyl groups, AOPP, and glycated hemoglobin), hepatic damage markers (GGT, SGOT), and parameters related to insulin resistance (HOMA, blood insulin, and blood glucose) correlate significantly with serum ferritin. Volunteers had an excessive iron intake, principally by bread consumption. Analyses of food intake showed that red meat consumption correlates significantly with serum ferritin. Conclusion. Red meat consumption, metabolic syndrome, and chronic disease markers are associated with hyperferritinemia in a population of Chilean men.