Calcium Channel Blockers, Progression to Dementia, and Effects on Amyloid Beta Peptide Production

Figure 2

Plot of the estimated rate of decline in MMSE scores across the age span: top curve (light blue) shows patients who were APOE negative who used CCBs; the 2nd curve (black) shows APOE-4 negative patients without CCB use; the third curve (red) which lies just below the 2nd is for APOE-4 positive subjects who used CCBs; and the bottom curve (dark blue) is APOE-4 positive subjects who did not use CCBs.