Role of Circulating miRNAs as Biomarkers in Idiopathic Pulmonary Arterial Hypertension: Possible Relevance of miR-23a

Figure 1

Circulating miRNAs differentially expressed in IPAH patients compared with healthy volunteers. Circulating miRNAs were extracted from blood from 12 IPAH patients and 10 healthy volunteers and analyzed using Affymetrix miRNA arrays. The -test following the false discovery rate (FDR) value correction was used to detect significant changes. Hierarchical clustering (a) and principal component analysis (PCA, (b)) were used to analyze the data obtained.

(a)

(b)