Oxidative Medicine and Cellular Longevity / 2015 / Article / Tab 1

Review Article

Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative Stress

Table 1

Potential cardiotoxicity induced by numerous chemotherapeutic agents.

ClassExamples of chemotherapeutic agentsPossible cardiotoxicity

Anthracyclines and anthraquinonesDOX, mitoxantroneCongestive heart failure, left ventricular dysfunction, acute myocarditis, and arrhythmia

Antimetabolite agentsCapecitabine, 5-fluorouracil, and cytarabineIschemia, pericarditis, congestive heart failure, and cardiogenic shock

Antimicrotubule agentsPaclitaxel, vinca alkaloidsSinus bradycardia, ventricular tachycardia, atrioventricular block, hypotension, congestive heart failure, and ischemia

Alkylating agentsCyclophosphamide, ifosfamideNeurohumoral activation, mild mitral regurgitation

Monoclonal antibody against HER2 TrastuzumabArrhythmias, congestive heart failure, angioedema, and left ventricular dysfunction

Antiangiogenic and tyrosine kinase inhibitorsImatinib, sorafenib, and sunitinibHypertension, arrhythmias

Antivascular endothelial growth factorBevacizumabHypertension, thromboembolism