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Oxidative Medicine and Cellular Longevity
Volume 2015 (2015), Article ID 803942, 8 pages
http://dx.doi.org/10.1155/2015/803942
Review Article

Alzheimer’s Pathogenesis and Its Link to the Mitochondrion

Department of Experimental and Clinical Medicine, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy

Received 30 December 2014; Revised 16 March 2015; Accepted 2 April 2015

Academic Editor: Trevor A. Mori

Copyright © 2015 C. Simoncini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Alzheimer’s disease (AD) is the most common form of dementia in the elderly. This neurodegenerative disorder is clinically characterized by impairment of cognitive functions and changes in behaviour and personality. The pathogenesis of AD is still unclear. Recent evidence supports some role of mitochondria dysfunction and oxidative stress in the development of the neurodegenerative process. In this review, we discuss the role of mitochondrial dysfunction in AD, focusing on the mechanisms that lead to mitochondrial impairment, oxidative stress, and neurodegeneration, a “vicious circle” that ends in dementia.