Association of Age-Related Macular Degeneration with Erythrocyte Antioxidant Enzymes Activity and Serum Total Antioxidant Status

Table 1

Difference of median erythrocyte SOD, GPx, and CAT activities and serum TAS between AMD patients and healthy control group; association of decrease in markers activity with AMD.

	AMD	Control	(95% CI)			Multivariate^*
	()	()				OR (95% CI)
TAS mmol/L	1.47 (1.33–1.71)	1.64 (1.47–1.77)	−0.17 (−0.28–−0.05)	10%	0.015	2.34 (1.42–3.86)	0.001
GPx U/gHb	39 (33–48)	54 (43–62)	−15 (−21–−9)	28%	<0.001	4.10 (2.19–7.70)	<0.001
SOD U/gHb	1389 (1185–1601)	1413 (1221–1575)	−25 (−166–116)	2%	0.984	1.10 (0.68–1.79)	0.701
CAT U/gHb	52 (48–58)	54 (47–60)	−2 (−6–2)	4%	0.426	0.70 (0.41–1.20)	0.191

Values are presented as median (interquartile range).
AMD = age-related macular degeneration; TAS = serum total antioxidant status index; GPx = glutathione peroxidase; SOD = superoxide dismutase; CAT = catalase.
= Mann-Whitney test with Monte Carlo two-tailed statistical significance based on 10.000 sampled tables; = absolute difference between medians; = relative difference between medians; 95% CI = 95% confidence interval of difference between medians; OR = odds ratio for AMD at unit decrease of standardized markers’ values, multivariate (adjusted) binary logistic regression.
Values of TAS, GPx, SOD, and CAT were standardized before the multivariate logistic regression analysis; arithmetic mean was subtracted and the difference was divided by standard deviation.