A Nitric Oxide-Donor Furoxan Moiety Improves the Efficacy of Edaravone against Early Renal Dysfunction and Injury Evoked by Ischemia/Reperfusion

Figure 4

Effects of EDV and NO-EDV on markers of oxidative stress in kidney samples. MDA levels (a) and MnSOD expression (b) were measured subsequent to sham operation (sham) or renal ischemia-reperfusion injury in the absence (vehicle) or presence of EDV (1.2–30 μmol/kg, i.v.) or NO-EDV (0.3–6 μmol/kg, i.v.). Data are expressed as mean ± S.E.M. versus vehicle.

(a)

(b)