A Nitric Oxide-Donor Furoxan Moiety Improves the Efficacy of Edaravone against Early Renal Dysfunction and Injury Evoked by Ischemia/Reperfusion

Figure 7

Effects of EDV and NO-EDV on cytokine production in kidney samples. TNF-α (a), IL-6 (b), IL-1β (c), and IL-18 (d) levels were measured in the kidney of sham-operated rats (sham) and rats that underwent 45 min ischemia and 6 h reperfusion in the absence (vehicle) or presence of EDV (1.2–30 μmol/kg, i.v.) or NO-EDV (0.3–6 μmol/kg, i.v.). Data are mean S.E.M. versus vehicle.

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