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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 836301, 12 pages
Research Article

Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice

1Center of Biomedical Research, Faculty of Health Sciences, Universidad Autónoma de Chile, Ricardo Morales 3369, 8910132 Santiago, Chile
2Center for Biomedical Research, Faculty of Biological Sciences and Faculty of Medicine, Universidad Andres Bello, República 217, 8370146 Santiago, Chile
3iEng Solutions Ltd., London N12 0DR, UK
4Department of Chemical Sciences, Faculty of Exact Sciences, Universidad Andres Bello, República 275, 8370146 Santiago, Chile
5Millennium Institute of Immunology and Immunotherapy, Santiago, Chile

Received 30 January 2015; Revised 8 May 2015; Accepted 11 May 2015

Academic Editor: Victor M. Gonzalez

Copyright © 2015 Lina M. Ruiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Quercetin, a dietary flavonoid used as a food supplement, showed powerful antioxidant effects in different cellular models. However, recent in vitro and in vivo studies in mammals have suggested a prooxidant effect of quercetin and described an interaction with mitochondria causing an increase in production, a decrease in ATP levels, and impairment of respiratory chain in liver tissue. Therefore, because of its dual actions, we studied the effect of quercetin in vivo to analyze heart mitochondrial function and erythropoiesis. Mice were injected with 50 mg/kg of quercetin for 15 days. Treatment with quercetin decreased body weight, serum insulin, and ceruloplasmin levels as compared with untreated mice. Along with an impaired antioxidant capacity in plasma, quercetin-treated mice showed a significant delay on erythropoiesis progression. Heart mitochondrial function was also impaired displaying more protein oxidation and less activity for IV, respectively, than no-treated mice. In addition, a significant reduction in the protein expression levels of Mitofusin 2 and Voltage-Dependent Anion Carrier was observed. All these results suggest that quercetin affects erythropoiesis and mitochondrial function and then its potential use as a dietary supplement should be reexamined.