Insulin Therapy of Nondiabetic Septic Patients Is Predicted by para-Tyrosine/Phenylalanine Ratio and by Hydroxyl Radical-Derived Products of Phenylalanine
Table 1
Baseline demographics, clinical data, and amino acid parameters of patients.
25
Age years]
69 ± 14
Male/female
14/11
Body weight kg]
80 (13)
Source of sepsis
Lung
13
Kidney
2
Burned skin
7
Wound
1
Abdomen
2
APACHE II
16 (10)
MODS
5 (5)
SAPS II
37.5 (20)
Serum creatinine µmol/L]
118 95.5
hsCRP mg/L]
154.2 ± 92.8
PCT ng/mL]
7.62 19.23
Daily urine output mL]
2055 (1775)
Mean daily glucose mmol/L]
9.0 2.5
DID U/day]
19 (25)
IGP U*mmol/L]
183.4223 261.2992
Number of patients receiving hydrocortisone
18 (72%)
Daily hydrocortisone dose mg/day]
200 (100)
Number of patients receiving dobutamine
10 (40%)
Daily dobutamine dose [mg/day]
275.0 537.5
Serum p-Tyr µmol/L]
45.177 ± 18.049
Serum m-Tyr nmol/L]
14 (27)
Serum o-Tyr nmol/L]
14 (15)
Serum Phe µmol/L]
65.374 ± 27.519
Serum p-Tyr/Phe µmol/µmol]
0.654 0.292
Serum m-Tyr/Phe nmol/µmol]
0.2 0.4
Serum o-Tyr/Phe nmol/µmol]
0.2 0.4
Serum m-Tyr/p-Tyr nmol/µmol]
0.3 0.5
Serum o-Tyr/p-Tyr nmol/µmol]
0.3 0.5
Serum (m-Tyr+o-Tyr)/Phe nmol/µmol]
0.5 0.7
Serum (m-Tyr+o-Tyr)/p-Tyr nmol/µmol]
0.6 1.1
Urinary p-Tyr µmol/L]
25.394 44.402
Urinary m-Tyr nmol/L]
123 (351)
Urinary o-Tyr nmol/L]
194 (661)
Urinary m-Tyr/p-Tyr nmol/µmol]
4 (17)
Urinary o-Tyr/p-Tyr nmol/µmol]
9 (39)
Urinary (m-Tyr+o-Tyr)/p-Tyr nmol/µmol]
21 (85)
Urinary p-Tyr/creatinine µmol/mmol]
6.952 11.645
Urinary m-Tyr/creatinine nmol/mmol]
29 (68)
Urinary o-Tyr/creatinine nmol/mmol]
61 (220)
Daily excretion of p-Tyr µmol/day]
56.268 116.710
Daily excretion of m-Tyr nmol/day]
259 (607)
Daily excretion of o-Tyr nmol/day]
304 (1786)
Clearance of p-Tyr mL/min]
0.605 1.720
Clearance of m-Tyr mL/min]
9.011 27.413*
Clearance of o-Tyr mL/min]
17.198 105.512*†
FE [%]
1.783 2.160
FE [%]
25.104 54.305‡
FE [%]
85.645 639.219
versus clearance of p-Tyr; versus clearance of m-Tyr; versus FEp-Tyr; vs. FEm-Tyr. APACHE II, acute physiology and chronic health evaluation II; MODS, multiple organ dysfunction score; SAPS II, simplified acute physiology score II; DID, daily insulin dose; IGP, insulin-glucose product; FE, fractional excretion. Data expressed as mean ± SD or median (interquartile range).
