Insulin Therapy of Nondiabetic Septic Patients Is Predicted by para-Tyrosine/Phenylalanine Ratio and by Hydroxyl Radical-Derived Products of Phenylalanine

Table 2

Predictors of carbohydrate metabolism parameters among septic patients, across the whole study period.

	DID		IGP^*
Serum Phe	−0.450	0.001	−0.460	0.001
Serum p-Tyr/Phe	0.507	<0.001	0.554	<0.001
Serum o-Tyr/Phe	—	—	0.280	0.049
Urinary m-Tyr	0.381	0.007	0.382	0.007
Urinary m-Tyr/p-Tyr	0.359	0.011	0.351	0.013
Urinary o-Tyr/p-Tyr	0.322	0.023	0.308	0.030
Urinary (m-Tyr+o-Tyr)/p-Tyr	0.389	0.006	0.376	0.008

Model: body weight, hsCRP, PCT, daily hydrocortisone dose, daily dobutamine dose, and the actual amino acid parameter.
DID, daily insulin dose; IGP, insulin-glucose product.
^*Calculated by average daily glucose level (mmol/L) multiplied by daily insulin dose (U).
Method: stepwise.