Role of Oxidative Stress in Thyroid Hormone-Induced Cardiomyocyte Hypertrophy and Associated Cardiac Dysfunction: An Undisclosed Story

Figure 2

Markers of oxidative damage in the hyperthyroid hearts. Oxidative damage of (1) lipid as assessed by measuring by-products of lipid peroxidation such as thiobarbituric acid reactive substances (TBARS), hydroperoxides, chemiluminescence, and/or -(malondialdehyde)lysine (MDA), (2) protein as assessed by estimating protein-bound carbonyls (C=O), and (3) genomic DNA estimated as 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG). In this study [45], old rats showed increased lipid peroxidation; however, young rats displayed no change. Representative images of thyroid gland, DNA, lipid, and protein are copied from Wikipedia under the Creative Commons Attribution-Share Alike 3.0 Unported License, which allows sharing and/or remixing.